Advances in Peripheral Nerve Repair and Regeneration

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Abstract

Peripheral nerve repair and regeneration still faces challenges with functional recovery, even after surgical nerve repair with modern allograft scaffolds/conduits and microsuturing techniques.  Technology must continue to advance in order to more effectively and efficiently regain original function and structure. This presentation will show ongoing work to improve peripheral nerve regeneration in four topic areas of current exploration in animal models; these include growth factors, neural tissue engineering using stem cells, gene editing, electrical stimulation and immunosuppression.

Learning Objectives

• Understand the current advances in trigeminal peripheral nerve repair and the current outcomes achieved.
• Understand the challenges that inhibit or prevent complete sensorimotor recovery of peripheral nerves despite modern advances in surgical technique.
• Describe four technologies that positively affect the effectiveness and efficacy of peripheral nerve repair and regeneration.
• Discuss the pros and cons of each of the new advances in peripheral nerve regeneration for translation to human peripheral nerve repair.