Developing a Challenging Preclinical Model of Compromised Wound Healing

Abstract
The craniomaxillofacial (CMF) region is highly complex, composed of morphologically intricate skeletal elements, extensive neural and vascular networks, special sense organs, lining tissues, and the dentition. The loss of tissue owing to traumatic, developmental, and pathological etiologies in a relatively small region presents a considerable reconstructive challenge. Treatment is further complicated in compromised wound healing environments. We will discuss the development of a clinically relevant, reproducible model of compromised wound healing, and how it can be used to inform future strategies aimed at improving bone regeneration in these situations.

Learning Objectives
1. Provide an overview of the complexities and challenges of treating patients with complex craniofacial bone defects.
2.Learn about multiple preclinical models used to evaluate bone regeneration in the maxillofacial complex.
3. Under stand how a new preclinical model of compromised wound healing was developed, characterized, and can be used to test bone grafting strategies.