Growth Factors: Autogenous, Allogeneic and Recombinant and Their Application to Bone Regeneration

Abstract: Bone regeneration represents a complex progression of events orchestrated by cellular and soluble factor contributions. This presentation will briefly describe contributions from inflammatory, neurogenic, vascular, and stromal/stem cells to bone regeneration.  Growth factors, Cytokines and Chemokines that direct regeneration will be identified.    Factor specific cell surface receptors, cytoplasmic messengers, and related nuclear transcription factors will be reviewed.  Sources of growth factors available to the surgeon will be discussed.

Learning Objectives:
1). Identify basic cell types active in bone regeneration.
2). Identify key growth factors, Cytokines and Chemokines that contribute to bone graft regeneration.
3). Understand Specific growth factors, target cells and  Cell surface receptors
4).Understand Cytoplasmic messenger factors.
5). Identify specific nuclear transcription factors associated with growth factors.
6). Discuss growth factors currently available for surgeons to use derived from, autogenous, allogeneic, and recombinant sources