Novel Approaches for Bone Grafting the Compromised Wound Healing Environment

Abstract
The reconstruction of large, morphologically complex maxillofacial bone defects continues to be a challenge for surgeons. Treatment is further complicated in compromised wound healing environments. We present two novel materials for bone regeneration in these clinically challenging scenarios: 1) Bioactive, 3D-printed ceramic scaffolds, and 2) Plasma Enhanced Chemical Vapor Deposition (PECVD) of semiconductor-based coatings. Promising preclinical data shows these strategies have the capacity to regenerate bone in irradiated critical-size defects and have strong potential for clinical translation.

Learning Objectives
1. Discuss biomaterial concepts for tissue replacement and tissue-material interactions.
2. Learn how direct inkjet written 3D-printed bioceramic scaffolds can be used to create patient-specific bone grafting materials.
3. Understand how semiconductor-based coatings can drive osteoinductive and angiogenic responses in bone healing.