Soft Biomaterials For Hard Tissue Formation

Abstract: The musculoskeletal system is the framework for structure, movement, posture, and stability, and defects or disorders in musculoskeletal tissues impair quality of life. My research is directed toward incorporating cues from the native environment and natural extracellular matrix (ECM) into the design of platforms and musculoskeletal tissue engineered constructs. By applying fundamental principles in cell and molecular biology, biomaterials, and biotransport phenomena, we are developing materials-based strategies to direct the behavior of transplanted or host cells within bone and cartilage defects and interrogate the behavior of various cell populations in more physiologically relevant conditions. In this talk, I will present examples of our recent work in designing biomaterials from cells and natural and synthetic polymers to instruct cell fate and enhance tissue formation and function with applications in musculoskeletal tissue regeneration and repair, with a particular focus on the craniomaxillofacial region. I will highlight the use of granular hydrogels to combat inflammation and promote bone and cartilage tissue formation, as well as the utility of instructive cell-secreted matrices to guide cell fate.

Learning Objectives:
1). Describe the influence of inflammation on musculoskeletal tissue repair and regeneration.
2). Share current efforts to promote bone formation in an inflammatory milieu.
3). Identify opportunities to propel new approaches for bone regeneration in the head and neck region and throughout the skeleton.