Today, large bony defects of the mandible and maxilla can be fully reconstructed without harvesting autogenous bone. This is accomplished in a straightforward manner by developing a graft in the operating room that completes the tissue engineering triangle of cells-signal-matrix. This uses a bone marrow aspirate as the source of cells as well as a contribution to the matrix, recombinant human bone morphogenetic protein-2 Acellular Collagen Sponge (rhBMP-2/ACS) as the signal, and cancellous allogeneic bone as the matrix. This graft system is referred to as in-situ tissue engineering. This graft consolidates sufficiently in six months to support dental implant placements and grows normally in a growing child. The advantages of this graft system, which essentially replaces autogenous bone, is a reduced time of surgery, reduced hospitalization, less pain for the patient, a faster return to the workplace and family, and less cost to the health care system. This graft system is also a predictable replacement for autogenous bone grafting in sinus augmentations, cystic defects, and
- The attendees to learn the principles of in-situ tissue engineering.
- The attendees to learn how to harvest bone marrow stem cells in a safe and straightforward manner.
- The attendees to learn how to combine the cells-signal-and matrix in appropriate doses for the best outcome.
- The attendees to understand the timing of bone regeneration and bone maturation for effective dental implant placements.
Robert Marx, DDS
Robert E. Marx, DDS, is Professor of Surgery and Chief of the Division of Oral and Maxillofacial Surgery at the University of Miami Miller School of Medicine as well as Chief of Surgery at Jackson South Community Hospital in Miami, He is well known as an educator, researcher, and innovative surgeon. He has pioneered new concepts and treatments for pathologies of the oral and maxillofacial area as well as new techniques in reconstructive surgery including stem cell therapies.
His many prestigious awards, including the Harry S. Archer Award, the William J. Giles Award, the Paul Bert Award, the Donald B. Osbon Award, and the Daniel Laskin Award, attest to his accomplishments and commitment to the field of oral and maxillofacial surgery.
His textbook “Oral and Maxillofacial Pathology: A Rationale for Diagnosis and Treatment” has also won the American Medical Writers Associations Prestigious Book of the year Award and his other textbooks “Platelet Rich Plasma: Dental and Craniofacial Applications”, “Tissue Engineering”, “Oral and Intravenous Bisphosphonates Induced Osteonecrosis”, and an “Atlas of Bone Harvesting” have been best sellers. He is also a writer of fiction medical mystery novels. His first publication “Deadly Prescription” is currently a “Best Seller” on Amazon.