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Osteo Science Foundation 2022 Meeting,
“Regenerative Solutions to Common Problems”


Did you miss our meeting in Austin? Don’t worry! You can watch all the presentations here.

Austin, TX


Description: Join us for a two-day event in Austin, Texas to hear experts in regenerative medicine discuss Regenerative Solutions to Common Problems 
: February 18-19, 2022
Location: Four Seasons – Austin, Texas
Cost: $595 General; $395 Military; $50 Resident & Full-Time Graduate Students

Topics include:

  • Bone Augmentation
  • Soft Tissue Substitutes
  • Soft Tissue Grafting Around Dental Implants
  • Bone Grafting Complications
  • Medication-related osteonecrosis
  • Development of a Compromised Maxillofacial Wound Healing Model for Bone Graft Evaluation
  • Peri-Impantitis Management
  • Sinus Grafting 30 Years: Myths and Realities

Schedule of Events

Updated Austin Meeting Schedule

*Note: schedule of events is subject to change

Speakers and Presentation Abstracts

Speakers and Presentation Abstracts

Dr. Dillom - Austin Meeting Speaker - Medication-Related OsteonecrosisJasjit Dillon, MBBS, DDS, FDSRCS, FACS

Medication-Related Osteonecrosis

Abstract, Learning Objectives and Bio


You have been referred a 65 female on a bisphosphonate for an extraction and immediate dental implant on #19. What is the best way to proceed? The patient wants to know her risk of medication-related osteonecrosis of the jaws (MRONJ) and what you will do to reduce it? This comprehensive overview of MRONJ will cover this and more. It will review medications that cause MRONJ and which ones are more problematic, along with the frequency and risk of disease. It will review risk and prevention strategies. The staging and current management including the latest research, clinical trials, and future treatment therapies will also be reviewed.

Learning Objectives
  1. Understand the etiology and risk of developing MRONJ
  2. Understand the risk of MRONJ with different classes of drugs
  3. Be aware of future preventative research in the management of MRONJ
Jasjit Dillion, MBBS, DDS, FDSRCS, FACS

Jasjit Kaur Dillon is Professor, Chief, and Program Director of Oral and Maxillofacial Surgery at the University of Washington, Seattle. She obtained her dental degrees from the University of Newcastle Upon Tyne (BDS), the University of California San Francisco (DDS) and her medical degree from St Bartholomew’s School of Medicine, University of London (MBBS). She is a member of the Royal College of Surgeons of England (FDSCRCS), the American College of Surgeons (FACS) and is an examiner for the American Board of OMFS. She has numerous peer reviewed scientific publications, book chapters, lectures nationally and internationally and is the principle investigator on a multi-centered clinical trial on medication related osteonecrosis of the jaw.

Bach Le, DDS, MD Bone Graft ComplicationsBach Le, DDS, MD

Bone Graft Complications


Point/Counterpoint: Vertical Defects in the Esthetic Zone Prosthetic or Surgical Solutions?” 

Abstract, Learning Objectives and Bio

Bone Graft Complications

Failures and complications associated with bone augmentation can have a devastating effect on the outcome of dental implant treatment. These complications are classified as either early or late. Early complications include wound dehiscence, membrane and graft exposure, and infection, with the most common complication being wound dehiscence. Late complications of bone augmentation are now recognized more frequently and include late resorption, foreign body reaction, late breakdown of grafted sites, lack of keratinized tissue and poor esthetics, as well as implant failure. This clinical presentation will focus on how to identify and avoid potential complications before they arise and how to manage many of the common complications that can occur with bone augmentation procedures. Emphasis will be given to risk assessment, classifications of complications, and treatment of challenging failures.

Learning Objectives
  1. Identify patient-related risk factors associated with bone augmentation procedures
  2. Identify anatomical-related risk factors associated with bone augmentation procedures
  3. Diagnose and treat complications related to bone augmentation surgery
Point/Counterpoint: Vertical Defects in the Esthetic Zone 
Prosthetic or Surgical Solutions?

Dr. Bach Le will be co-presenting this session with Dr. Craig M. Misch. The abstract and learning objectives for the session appear under Dr. Misch’s description.

Bach Le, DDS, MD

Dr. Bach Le completed his specialty training in Oral & Maxillofacial Surgery at Oregon Health Sciences University. He is currently a Clinical Associate Professor of Oral & Maxillofacial Surgery at the USC School of Dentistry. Dr. Le maintains a private practice in Whittier, California. Dr. Le has lectured both nationally and internationally on bone regeneration and dental implant-related surgery and has published extensively in scientific texts and professional journals. Dr. Le is a Diplomate of the American Association of Oral & Maxillofacial Surgeons, the American Dental Society of Anesthesiologist and the International Congress of Oral Implantologists, and holds Fellowship in the International College of Dentists, the American College of Dentists and the International Association of Oral & Maxillofacial Surgeons.

Robert A. Levine DDS, FCPP, FISPPS

Soft Tissue Grafting and the Importance of Phenotype Conversion Around Dental Implants: a Periodontal Plastic Surgeon’s Perspective

Abstract, Learning Objectives and Bio


There is growing evidence of the importance of both soft and hard tissue dimensions around dental implants in the prevention of short-term and long-term complications. This clinically oriented presentation will focus on the benefits of “phenotype conversion” using autogenous tissue grafts as well as collagen matrices whose usage comes with less patient morbidity. In addition, the use of bone-grafting substitutes to fulfill the “10 Keys for Successful Esthetic-Zone Immediate Implants” will be reviewed as it relates to long-term success. The clinical importance of the buccal gap dimension in the decision process to virtually plan an implant width will be reviewed. Lastly, Dr. Levine will share his conclusions of 4 publications in which he has co-authored with Dr. Mauricio Araujo (University of Maringa, Brazil) on a series of single tooth immediate central incisor implants placed in his private practice with CBCT and clinical analysis at greater than 1-year in function.

Learning Objectives
  1. Recognize and apply the benefits to your practice of the “10 Keys for Successful Esthetic-Zone Immediate Implants” as it relates to the diagnostic, surgical, and prosthetic phases 
  2. The importance of soft and hard tissue augmentation for usage in both esthetic and non-esthetic areas for long-term success from single tooth to full arch 
  3. Describe the indications and benefits for the use of a new volume-stable collagen matrix to augment soft tissue thickness around dental implants and its important role in “phenotype conversion” 
  4. To understand the recent documented evidence supporting the usage of “phenotype conversion” around dental implants including a series of clinical studies to be published by Dr. Levine and his clinical research group 
Robert A. Levine DDS, FCPP, FISPPS

Dr. Robert A. Levine practices at the Pennsylvania Center for Dental Implants and Periodontics in Philadelphia, PA. He holds teaching positions at Temple University, the University of North Carolina, and the University of Illinois.

Dr. Levine is a Diplomate of the American Board of Periodontology, a Fellow and President-Elect (2021) of the International Society of Periodontal Plastic Surgeons, a Fellow of the International Team for Implantology, and is on the Board of Directors for the Academy of Osseointegration. He serves on the editorial boards of numerous journals and has authored over 80 articles and book chapters.

Austin Speaker Nicholas MakhoulNicholas Makhoul, DMD, MD

Microvascular Reconstruction of the Maxilla and Mandible

Abstract, Learning Objectives and Bio


Reconstruction of the maxillofacial region poses many challenges and continues to be one of the most difficult tasks of an oral and maxillofacial surgeon.  In the past few decades, a focus on improving patient form and functionality has driven advancements in the field.  With the advent of free microvascular tissue transfer, patients requiring large hard and soft tissue reconstruction have had improved results that what was acceptable in the past. In addition, our application of computer aided design and manufacturing has made predictable functional reconstruction even more attainable. Even with these recent advancements our pursuit for perfection has yet to be realized as we explore new methods to solve an age-old problem.

Learning Objectives
  1. Review of principles for maxillofacial reconstruction.
  2. Free tissue reconstruction techniques.
  3. Use of computer aided surgical design and 3D printing in reconstruction.
  4. Future directions in facial reconstruction.
Nicholas Makhoul, DMD, MD

Dr. Makhoul is an academic clinician-scientist at McGill University with a specialization in maxillofacial reconstructive surgery. His research interests include tissue engineering composite vascularized flap for complex facial reconstruction as well as outcomes studies in patients undergoing complex maxillofacial surgery. Dr. Makhoul also heads the Maxillofacial surgery unit at McGill University and has an active clinical practice in a broad field of  Oral and Maxillofacial Surgery.

Robert E. Marx, DDS  Bone Augmentation Update - Austin Meeting 2021Robert E. Marx, DDS, FACS

Practical Access to Stem Cells for Oral and Maxillofacial Surgery

Abstract, Learning Objectives and Bio


Today’s, point of care in-situ tissue engineering can reconstruct large continuity defects of the mandible and cystic defects as well as regenerate sufficient bone to place dental implants with ridge augmentation procedures!

The components of predictable in-situ tissue engineering have been shown to be cells, a signal, i.e., rhBMP-2/ACS, and a matrix, i.e., cancellous allogeneic bone +/or fibrin, fibronectin, vitronectin. As defects become larger and the tissue bed becomes more compromised with scar, radiation, or poor vascularity, a greater number of osteoprogenitor cells/stem cells is required. Three existing bone marrow harvesters have shown the ability to regenerative bone in jaws to varying degrees. One system uses a straight trocar to remove 60 ml of a bone marrow aspirate which is centrifuged to a 10 ml concentrate. Another system uses a straight to trocar to harvest 10 ml of a bone marrow aspirate without the need to centrifuge. A third system uses a flex metric design to harvest 10 ml or more, if required, also without centrifugation and has shown superiority in stem cell yield, applicability to the office, better safety and reduced cost. Data on these three systems will be compared as well as outcomes in bone regeneration.

Learning Objectives

1. The attendee will learn where the largest number of stem cells and osteoprogenitor cells reside in the donor sites of the tibia, anterior ilium, and posterior ilium
2. The attendee will learn of appropriate markers for stem cells as well as the counts in CFU-f’s to look for to assess stem cell yield
3. The attendee will be able to assess and know the difference in bone marrow aspiration devices related to a need or not need for a centrifuge, a straight needle versus a flexible needle, and the value of aspirate upon removal of the needle or going forward

Robert E. Marx, DDS

Robert E. Marx, DDS, FACS, recently retired as Professor of Surgery and Chief of the Division of Oral and Maxillofacial Surgery at the University of Miami Miller School of Medicine and Chief of Surgery at Jackson South Medical Center. He is well known as an educator, researcher, and innovative surgeon. He has pioneered new concepts and treatments for pathologies of the Oral and Maxillofacial area as well as new techniques in reconstructive surgery including stem cell therapies.

His many prestigious awards, including the AAOMS Research Recognition Award twice, the Harry S. Archer Award, the William J. Giles Award, the Paul Bert Award, the Donald B. Osbon Award, and the Daniel Laskin Award, attest to his accomplishments and commitment to the field of Oral and Maxillofacial Surgery.

James Melville Austin SpeakerJames C. Melville, DDS, FACS

From Bench to Bedside: The Evolution of Tissue Engineered Maxillofacial Reconstruction

Abstract, Learning Objectives and Bio


First conceptualized by W.T. Green in the 1970s, the advent of tissue engineering was a significant milestone in the field of medicine and surgery. What started as proof-of-concept studies in preclinical models has transitioned to clinically applicable regenerative strategies for maxillofacial reconstruction in patients. Tissue-engineered bone grafts have made the reconstruction of defects of the oral and maxillofacial region predictable and reliable without the need for harvesting autogenous bone.

The “bench” part of this session will introduce and discuss the science regarding bone and nerve repair and regeneration.

The “bedside” session will focus on key concepts for the successful clinical application of tissue engineering science to bone and nerve repair. This session will briefly discuss preoperative workup, preparation, and procedural options for patients with tumors, post-resection defects, and traumatic defects.

Learning Objectives
  1. Discuss the fundamental science behind tissue-engineering with a focus on cutting-edge strategies for bone and nerve regeneration

  2. Review clinical strategies for bone and nerve regeneration to optimize patient outcomes

  3. Review surgical technique and management of complications

      James C. Melville, DDS, FACS

      James C. Melville, DDS, FACS, is an Associate Professor in the Department of Oral and Maxillofacial Surgery at the University of Texas Health Science Center at Houston UTHealth and specializes in Oral, Head & Neck Oncology and Microvascular Reconstructive Surgery. He graduated from the University of Michigan School of Dentistry in Ann Arbor, Michigan, in 2005 and completed a General Practice Residency at the University of California San Francisco in 2006. He completed a residency in oral and maxillofacial surgery in 2012, followed by fellowships in oral, head, and neck oncology and microvascular reconstructive surgery at the University of Miami/Jackson Memorial Hospital. He was appointed to the UTH OMFS internship director in 2017.

      Dr. Melville was awarded the Faculty Educator Development Award (FEDA) in 2019 by the American Association of Oral & Maxillofacial Surgeons (AAOMS). An award given to promising young academic surgeons. He was awarded the AAOMS Advocacy Challenge Coin by the AAOMS Board of Trustees and AAOMS Committee on Government Affairs in 2020. AAOMS designed its own Challenge Coin to recognize oral and maxillofacial surgeons who have made significant advocacy contributions on behalf of the Association. The AAOMS Challenge Coin is awarded to those elite few who transcend the efforts of their colleagues to further the specialty through advocacy. Dr. Melville will serve as the Vice-President of Oral & Maxillofacial Section of the International Dental Association of Researchers (IADR) starting in July 2021.

      Dr. Melville is a diplomate of the American Board of Oral and Maxillofacial Surgery and a fellow of the American Association of Oral and Maxillofacial Surgeons, the American Academy of Craniomaxillofacial Surgeons, American College of Oral & Maxillofacial Surgeons and the American College of Surgeons.

      He has written a Springer textbook on maxillofacial reconstruction and contributed to 18 chapters in textbooks concerning oral and maxillofacial surgery, oncology, maxillofacial reconstruction, microvascular reconstruction, and tissue engineering. In addition, he is the author of more than 30 articles in peer-reviewed journals. He is a reviewer for the Journal of Oral and Maxillofacial Surgery (JOMS), Triple OOOO Journal, Journal of Cranio-Maxillofacial Surgery, Journal of Tissue Engineering, Journal of Biomedical Materials Research, Experimental Dermatology and of Journal of American Dental Association (JADA).

      Michael K. McGuire, DDS Soft Tissue Substitutes - Austin Meeting 2021Michael K. McGuire, DDS

      Evidence-Based Alternatives to Autogenous Tissue: Outcomes, Attachment, and Stability

      Abstract, Learning Objectives and Bio


      Our goal in soft tissue reconstruction is to maximize clinical outcomes while reducing morbidity. New devices are being introduced that may be able to achieve these goals. This program will explore autogenous tissue alternatives along with evidence-based decision trees on when alternatives should be considered and how to improve outcomes.

      Learning Objectives

      Upon completion of this presentation, participants should be able to:

      1. Explain the objectives of soft tissue augmentation.
      2. Compare various techniques and how they differ from the gold standard.
      3. Discuss the advantages of alternative therapy.
      Michael K. McGuire

      Dr. McGuire is the primary author of over fifty scientific articles and textbook chapters, an unparalleled achievement for someone in full-time private practice. He serves on the editorial board of multiple publications and is the founder and chairman of the McGuire Institute, a not-for-profit practice-based clinical research network.

      An eminent speaker, having given over 200 continuing education programs, Dr. McGuire has lectured for both national and international audiences. His research has received the American Academy of Periodontology’s highest recognition for excellence, four times earning the Robinson Regeneration Award and twice the Clinical Research Award. He is also the recipient of the Academy’s prestigious Master Clinician Award and the Academy’s highest honor, the Gold Medal Award. In 2015 he received the William J. Gies Periodontology Award for his distinguished achievement in periodontology.

      Dr. McGuire is past Chairman of the American Board of Periodontology. He has served as president of numerous dental organizations, including the American Academy of Periodontology and the American Academy of Periodontology Foundation. He is a voting member of the FDA Dental Products Devices Panel. Emory University recognized Dr. McGuire with its Distinguished Alumnus Award in 2009.

      Craig M. Misch, DDS, MDS, PA  Bone Augmentation Update - Austin Meeting 2021Craig M. Misch, DDS, MDS

      Point/Counterpoint: Vertical Defects in the Esthetic Zone Prosthetic or Surgical Solutions?”

      This presentation will be co-presented with Bach Le, DDS, MD 

      Abstract, Learning Objectives and Bio


      Patients with missing teeth in the “esthetic zone” may present with severe hard and soft tissue loss. While many techniques offer excellent results for reconstruction of these defects, few can be said to guarantee success. A bone augmentation procedure to correct a vertical defect in the esthetic zone that is not fully successful in correcting the defect often ensures the use of prosthetic pink. This leads to the treatment dilemma: “if we have to use a little pink, why not use a lot of pink” and spare the patient the painful bone augmentation
      in the first place? The aim of this lecture is to critically evaluate the current evidence to determine the predictability of various bone augmentation techniques for vertical ridge defects for implant placement and when to consider more conservative alternative treatment options.

      Learning Objectives

      1. Discuss the methods for vertical bone augmentation in the anterior maxilla
      2. Understand the limitations of augmentation and implant replacement of multiple missing teeth in the esthetic zone
      3. Discuss surgical approaches to prepare the anterior maxilla for the prosthetic solution to defect management

      Criag M. Misch, DDS, MDS

      Dr. Craig Misch received certificates in postgraduate Prosthodontics and Oral Implantology, as well as a Master of Dental Science from University of Pittsburgh. Thereafter he became Co-Director of the University of Pittsburgh Oral Implantology Center. Dr. Misch then completed specialty training in Oral and Maxillofacial Surgery in Pittsburgh and is board certified by the American Board of Oral and Maxillofacial Surgery as well as the American Board of Oral Implantology/Implant Dentistry.  Dr. Misch practices as a dual specialist in Sarasota, Florida. He is a Clinical Associate Professor at the Universities of Florida, Alabama, Pennsylvania, and Michigan in the departments of periodontics and prosthodontics. Dr. Misch serves as  Editor in Chief of The International Journal of Oral Implantology and is on the editorial boards of the Journal of Oral Implantology and the International Journal of Periodontics and Restorative Dentistry. He has been a featured speaker for numerous organizations and has published extensively with over 50 publications and 20 textbook chapters.

      Austin Meeting SpeakerRobert Sader, MD, DDS, PhD

      Bone Augmentation and Reconstruction: Keystones to Stimulate the Regeneration Process

      Abstract, Learning Objectives and Bio


      Reconstruction of complex shaped vertical and lateral bony defects is still a challenging problem for the surgeon, and complications and failures in osseous regeneration constantly occur, especially when bone substitutes are used or blended or when the patient’s tissues are medically compromised. On the base of the human bone physiology and its regenerative healing mechanisms the fundamental mechano-biological keystones in surgical bone augmentation and reconstruction are presented in a step-by-step approach. Considering the biological requirements in unpredictable stability, early loading and enhanced neo-vascularisation by application of autologous blood concentrates, the complication rate can be reduced and bone augmentation can be performed more successfully even in very compromised patients such as in irradiated bone with application of advanced techniques.

      Learning Objectives
      1. Understand the bone physiology regarding its regeneration processes and capacities
      2. Assess the different available bone substitutes and surgical techniques
      3. Avoid complications by strictly following physiologically based surgical augmentation principles
      Robert Sader, MD, DDS, PhD

      Prof. Dr.mult. Robert Sader has received his training in OMF-Surgery at Technical University Munich. After working at University Hospital Basel, in 2004 he was appointed as professor, director, and chair of Oral, Cranio-Maxillofacial and Facial Plastic Surgery at Goethe-University Frankfurt. His department offers the whole spectrum from dentoalveolar and septic surgery, dental implantology, traumatology, orthognatics, TMJ surgery, oncology, plastic-reconstructive, and craniofacial surgery. In Frankfurt he is as well medical director and CEO of the University Dental Institute “Carolinum”. Since 2009 he is president of the German Academy of Aesthetic Dentistry and the Frankfurt Dental Association founded in 1863. Moreover, he is Executive Board Member of the International Foundation of Cleft Lip and Palate, Educational Board Member of the Osteo Science Foundation and the International Association of Oral and Maxillofacial Surgery and General Secretary elect of the International Federation of Esthetic Dentistry. Since 2018 he is the President of the Oral Reconstruction Foundation.

      Frank Schwarz, DMD Peri-Implantitis Management - Austin Meeting 2021Frank Schwarz, DMD

      Treatment Concepts for the Management of Peri-Implantitis

      Abstract, Learning Objectives and Bio


      Previous studies have indicated that surgical treatment of peri-implantitis with concomitant placement of a bone filler is associated with clinical and radiographic improvements on both short- and long-term periods. However, the available evidence also suggests, that the effectiveness of regenerative treatment approaches is influenced by several factors, such as the type and configuration of the defect and implant surface characteristics, as well as the method of surface decontamination.

      Learning Objectives
      1. Surgical techniques and materials for regenerative therapy of peri-implantitis associated defects
      2. Various decontamination protocols
      3. Combination procedures for advanced defects (resective/regenerative)
      4. The indication for soft tissue volume grafting
      5. Indication based flap and suturing techniques
      Frank Schwarz, DMD

      Frank Schwarz is Professor and Chairman of the Department of Oral Surgery and Implantology at the Centre for Dentistry and Oral Medicine (Carolinum), Johann Wolfgang Goethe-University Frankfurt, Germany. He serves as an Associate Editor for the Journal of Clinical Periodontology and Editorial Board Member for Clinical Oral Implants Research. He is past President of the German Association of Oral Implantology (DGI), Executive Board Member of the Osteology Foundation and was awarded the André Schröder Research Prize in 2007, the Miller Research Prize in 2012, and the Jan Lindhe Award in 2017.

      Simon Young, DDS, MD, PhD Development of a Compromised Maxillofacial Wound Healing Model for Bone Graft Evaluation - Austin Meeting 2021Simon Young, DDS, MD, PhD, FACS

      From Bench to Bedside: The Evolution of Tissue Engineered Maxillofacial Reconstruction

      Abstract, Learning Objectives and Bio


      First conceptualized by W.T. Green in the 1970s, the advent of tissue engineering was a significant milestone in the field of medicine and surgery. What started as proof-of-concept studies in preclinical models has transitioned to clinically applicable regenerative strategies for maxillofacial reconstruction in patients. Tissue-engineered bone grafts have made the reconstruction of defects of the oral and maxillofacial region predictable and reliable without the need for harvesting autogenous bone. At the same time, the use of allogeneic nerve has revolutionized nerve repair and changed the concept of sensory recovery after trauma and ablation. The focus of this session will be on the two fields where the most significant advancements have occurred, craniofacial bone and sensory nerves. Multiple long-term clinical studies have demonstrated tissue-engineered bone grafts and allogeneic nerve reconstruction are equivalent or even superior to autogenous grafts.

      The “bench” part of this session will introduce and discuss the science regarding bone and nerve repair and regeneration. Emphasis will be placed on state-of-the-art science regarding growth factors, autogenous bone substitutes, and allogeneic grafts.

      The “bedside” session will focus on key concepts for the successful clinical application of tissue engineering science to bone and nerve repair. This session will briefly discuss preoperative workup, preparation, and procedural options for patients with tumors, post-resection defects, and traumatic defects. Focus areas will include surgical technique, postoperative care, and the management of complications.

      Learning Objectives
      1. Discuss the science behind bone grafts, tissue-engineering graft, Allogeneic Nerve regeneration
      1. Review surgical techniques to optimize bone and nerve regeneration and patient outcomes
      1. Review Surgical Technique and Management of Complications
      Simon Young, DDS, MD, PhD

      Dr. Young is a board-certified Oral and Maxillofacial Surgeon with an interest in the treatment and reconstruction of craniomaxillofacial trauma and pathology. He has broad experience in the fields of polymer synthesis, polymer characterization, growth factor delivery, in vivo models and characterization of bone and neovascularization. His research efforts include the synthesis and characterization of implantable materials designed to elicit in situ cell recruitment and programming. One aspect of this work includes the use of materials able to simultaneously deliver multiple growth factors with distinct release profiles, for the promotion of bone regeneration in the craniomaxillofacial complex.

      Puhan HePuhan He, DMD


      A Fibrin Hydrogel Encapsulated with Gingival-Derived MSC Extracellular Vesicle-Laden Small Intestine Submucosa Construct Promotes Tongue Myomucosal Regeneration in Rats

      Abstract & Bio


      Reconstruction of large craniofacial tissue defects remains one of the major challenges in OMFS. Currently, microvascular soft tissue free flaps are the gold standard for tongue reconstruction. However, these free flaps do not allow
      for both structural and functional restoration of the tongue and may result in donor site morbidity. This team has previously demonstrated that the use of gingiva-derived mesenchymal stem cells and their derivative cell-free products, extracellular vesicles (GMSC-EV), could facilitate myomucosal regeneration in rat tongues. This work aims to bring the regenerative product closer to clinical application by using GMSC-EVs encapsulated in fibrin hydrogel as a delivery system, allowing more sustained release of EVs, in a critical-sized tongue defect model in rats.

      Puhan He, DMD 

      Dr. Puhan He is a PGY-3 OMFS resident at the Hospital of the University of Pennsylvania. Her current clinical and research interests include reconstructive craniomaxillofacial surgery, regenerative medicine, and global surgery. She is a current Osteo Science Foundation Resident Research recipient for her project in tongue myomucosal regeneration.

      daileyMatthew Dailey, DDS, MD


      Scaffold-Free Facial Nerve Conduit Engineered Using Dental Pulp Stem Cells

      Abstract & Bio


      Current treatments of facial nerve injury result in poor functional outcomes due to inefficient axon regeneration and aberrant reinnervation of target muscles. To address these clinical challenges, bioactive scaffold-free cell sheets were engineered using dental pulp stem cells and their aligned extracellular matrix (ECM). Dental pulp stem cells (DPCs) endogenously supply high levels of neurotrophic factors (NTFs), and an aligned extracellular matrix provides guidance cues to direct axon extension. Human DPCs were grown on a substrate comprising parallel micro-grooves, inducing the cells to align and deposit a linearly aligned, collagenous ECM. The resulting cell sheets were robust and manipulable. DPC sheets produced NTFs at levels previously shown capable of promoting axon regeneration. The aligned DPC sheets were able to stimulate functional neuritogenic effects in neuron-like cells in vitro. Neuronally differentiated neuroblastoma cells produced neurites that were significantly more oriented and less branched when cultured on aligned cell sheets relative to unaligned sheets. Our data demonstrates that the linearly aligned DPC sheets can both support axon regeneration and improve axonal guidance which, when applied to a facial nerve injury, will result in more accurate reinnervation.

      Matthew Dailey, DDS, MD

      Matthew Dailey is a PGY-5 resident in the OMFS program at the University of Pittsburgh Medical Center. He obtained his DDS from the University of California, Los Angeles in 2013. Following graduation, Dr. Dailey entered the U.S. Air Force, completed a one year Advanced Education in General Dentistry residency and served an additional three years. Dr. Dailey’s surgical interests are in reconstruction and craniofacial surgery. He is an Osteo Science Foundation Resident Research recipient.

      *Note: Speakers are subject to change

      Osteo Science Foundation would like to thank the support of all our generous sponsors:


      Hotel Information

      A room block has been made at the Four Seasons Austin, which is the site of the meeting (
      Reservations must be made by calling the hotel directly at 512-685-8100.  Please reference Osteo Science Foundation in order to receive the discounted rate of $319/night plus applicable occupancy and sales tax. Rates are subject to applicable sales and occupancy taxes, which are currently 15% but are subject to change.  A $4.50 state-cost recovery fee will be added to each room. *Please note that you will not be extended the discounted rate if you book online.

      Four Seasons


      Austin Bergstrom International Airport is 20 minutes from the Four Seasons; additional hotel options can be found near the airport.

      While a room block has only been made at the Four Seasons, there are budget-conscious hotel options nearby, including the following:

      Hyatt Place Austin Downtown
      211 E 3rd St, Austin, TX 78701•(512) 476-4440
      4-minute drive from the Four Seasons

      Aloft Austin Downtown
      109 East 7th Street, Austin, Texas 78701 +1 512-476-2222
      6-minute drive from the Four Seasons

      Hampton Inn & Suites Austin-Downtown/Convention Center
      200 San Jacinto Blvd, Austin, TX 78701•(512) 472-1500
      5-minute drive from the Four Seasons

      Extended Stay America – Austin – Downtown – Town Lake at 507 S 1st St, Austin, TX 78704, (512) 476-1818
      5-minute drive from the Four Seasons

      Continuing Education


      This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of PeerPoint Medical Education Institute, LLC and Osteo Science Foundation. The PeerPoint Medical Education Institute, LLC is accredited by the ACCME to provide continuing medical education for physicians.


      The PeerPoint Medical Education Institute, LLC designates this live activity for a maximum of 15.25 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

      PACE Academy of General Dentistry logo

      Osteo Science Foundation

      Nationally Approved PACE Program Provider for FAGD/MAGD credit.

      Approval does not imply acceptance by any regulatory authority, or AGD endorsement.

      7/1/18 to 6/30/24

      Provider ID: 370582

      Poster Submissions

      Two abstracts have been selected by the OSF Education Committee for a 10 minute oral presentation during the plenary session on the first day of the conference (Friday, February 18, 2022). 

      COVID Protocols

      Like many professional meeting organizers, the Osteo Science Foundation has struggled with developing guidelines for our in-person educational events in the age of COVID. This is particularly true when so many individuals have worked so hard to produce an academic program of the highest quality and the Foundation has invested significant resources towards our events. We understand that there are differing opinions, incomplete science, and continuously evolving safety standards. However, as healthcare providers, the Directors of the Osteo Science Foundation believe that acknowledgement of and compliance with the current guidelines proposed by the CDC for personal safety should be followed. Accordingly, we ask that all attendees of our upcoming regenerative medicine symposium adhere to the following standards:

      1. Daily honest and vigilant self-screening assessments of your personal status before attending our program.

      1. If you develop any symptomatology suggestive of COVID (fever, upper respiratory infection, cough, malaise, loss of taste or smell) please isolate yourself and notify the organizers ( We will refund your registration fee, and will make recordings of the meetings available to you as soon as they are available. Unfortunately, we are not able to refund or reimburse any travel or lodging expenses.

      1. Rapid antigen tests will be available on-site for those who wish to use them. If you are symptomatic (see #2 above), please follow the procedures outlined above and isolate yourself, and do not rely on a negative test to determine your COVID status. These are used as tools to help identify positive cases but not to rule out COVID among individuals who are symptomatic, since we know that the Rapid antigen tests are not 100% accurate.

      2. Mask wearing during all indoor events not associated with eating or drinking. Masks will also be made available during our event.

      3. Hand hygiene using available hand sanitation stations throughout the meeting area.

      4. Strong encouragement to be completely vaccinated with boosters despite the apparent lack of protection against infection currently reported with the latest omicron variant.

      1. To the extent possible, attendees will be seated 6’ from other attendees in the meeting hall, in an effort to socially distance.

      1. Weather-permitting, all meals will be served outdoors.

        If you have any questions or concerns about these guidelines, please reach out to the organizers and we will address your issues.

      Mark E. Wong, FACD, FACS
      Professor and Bernard and Gloria Katz
      Chair of Oral and Maxillofacial Surgery

      We're sorry, but all tickets sales have ended because the event is expired.

      *registration closes 2/14/2022

      Only 1 promo code may be used per registration. Promo codes cannot be applied to discounted ticket prices. 

      Cancellation Policy:
      For a full refundcancellations must be sent via email and  received by 2/10/22. After 2/10/22, no refunds will be issued. Telephone cancellations or voicemail messages will not be honored. Osteo Science Foundation reserves the right to cancel or postpone any course due to unforeseen circumstances. In the event of a cancellation or postponement, OSF will refund registration fees, but is not responsible for any related costs, charges, or expenses to participants. If you booked a room in the hotel block it is your responsibility to cancel and pay any accrued fees. 

      Please contact the Osteo Science Foundation Staff, Ashley Cusack at  if you have any questions or concerns or if you must cancel.


      Osteo Science Foundation
      475 Wall Street
      Princeton, NJ 08540
      855-891-2877 Toll Free

      Osteo Science Foundation is an independent, privately funded 501 (c) (3) non-profit organization. | PRIVACY POLICY


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