PUBLICATIONS
Research Publications
Hussein N, Ramagli L, Vivekanand Nayak V, Tailor R, F. Kurtis Kasper, Dharmaraj N, Coelho P, Mirsky N, Witek L, Norton W, Young S. A Compromised Maxillofacial Wound Healing Model for Characterization of Particulate Bone Grafting: An In Vivo Study in Rabbits. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2025; 113:e35556. February 6 2025. https://doi.org/10.1002/jbm.b.35556. Full Text
Feldman G, Young D, Freeman T, Israel L, Taub D, Diecidue R. Geranylgeraniol (GGOH), incorporated into a bone cement pellet promotes osteoclast function and healing in a model of medication-related osteonecrosis of the jaw. J Oral Biol Craniofac Res. 2024 Mar-Apr;14(2):126-132. doi: 10.1016/j.jobcr.2024.01.014. Epub 2024 Feb 1. PMID: 38327595; PMCID: PMC10847162.
Cho J, Feldman G, Tomlinson R, Taub D, Diecidue R. Medication-related osteonecrosis of the jaw (MRONJ) systemic review: mevalonate pathway mechanisms explored. Oral Surg Oral Med Oral Pathol Oral Radiol. 2024 Jun 3:S2212-4403(24)00317-1. doi: 10.1016/j.oooo.2024.05.014. Epub ahead of print. PMID: 38987158.
Zhang, Q, He, P, Shi, S, Xu, Q, Granquist, E, Winkelstein, B, Shanti, R, Le, A, 2024. Secretome enriched with small extracellular vesicles derived from human gingiva-derived mesenchymal stem cells enhances rat tongue muscle regeneration. Journal of Nanobiotechnology. Submitted.
Subbiah R, Lin EY, Athirasala A, Romanowicz GE, Lin ASP, Califano JV, Guldberg RE, Bertassoni LE. Engineering of an Osteoinductive and Growth Factor-Free Injectable Bone-Like Microgel for Bone Regeneration. Adv Healthc Mater. 2023 Feb 20:e2200976. doi: 10.1002/adhm.202200976. Epub ahead of print. PMID: 36808718. Full Text
Vasudev Vivekanand Nayak, Blaire V. Slavin, Edmara TP Bergamo, Andrea Torroni, Christopher M. Runyan, Roberto L. Flores, F. Kurtis Kasper, Simon Young, Paulo G. Coelho, and Lukasz Witek. “Three-Dimensional Printing Bioceramic Scaffolds Using Direct-Ink-Writing for Craniomaxillofacial Bone Regeneration.” Tissue Engineering Part C: Methods 29, no. 7 (2023): 332-345. Full Text
Vasudev Vivekanand Nayak, Daniel Boczar, Paulo G. Coelho, Andrea Torroni, Christopher M. Runyan, James C. Melville, Simon Young, Bruce Cronstein, Roberto L. Flores, and Lukasz Witek. “Innovative Treatment Modalities for Craniofacial Reconstruction.” In Advancements and Innovations in OMFS, ENT, and Facial Plastic Surgery, pp. 291-308. Cham: Springer International Publishing, 2023. Full Text
Alberto L, Kalluri L, Qu J, Zhao Y, Duan Y. Influence of Polycaprolactone Concentration and Solvent Type on the Dimensions and Morphology of Electrosprayed Particles. Materials. 2023; 16(5):21. Full Text
He, P, Xu, Q, Zhang, Q, Shanti, RM, and Le, A. Beyond free flaps: the promising role of GMSC-derived extracellular vesicles in tongue regeneration. Annual American Association of Oral and Maxillofacial Surgeons Conference. September, 2023.
T Ishii, M Ruiz‐Torruella, JY Kim, H Kanzaki, A Albassam, W Wisitrasameewong, S Shindo, Umadevi Kandalam. Soluble Sema4D cleaved from osteoclast precursors by TACE suppresses osteoblastogenesis. Journal of cellular and molecular medicine, 11 May 2023 https://doi.org/10.1111/jcmm.17416. Full Text
AE Lee, JG Choi, SH Shi, P He, QZ Zhang, A.D. Le. DPSC-Derived Extracellular Vesicles Promote Rat Jawbone Regeneration,” publication in the Journal of Dental Research. 11-2022. Abstract
Aytac Z, Dubey N, Daghrery A, Ferreira JA, de Souza Araújo IJ, Castilho M, Malda J, Bottino MC. Innovations in Craniofacial Bone and Periodontal Tissue Engineering – From Electrospinning to Converged Biofabrication. Int Mater Rev. 2022;67(4):347-384. doi: 10.1080/09506608.2021.1946236. Full Text
Daghrery A, de Souza Araújo IJ, Castilho M, Malda J, Bottino MC. Unveiling the potential of melt electrowriting in regenerative dental medicine. Acta Biomater. 2022 Jan 10:S1742-7061(22)00010-1. doi: 10.1016/j.actbio.2022.01.010. Full Text
Kalluri L, Duan Y. Parameter Screening and Optimization for a Polycaprolactone-Based GTR/GBR Membrane Using Taguchi Design. Int J Mol Sci. 2022 Jul 24;23(15):8149 (Impact Factor=6.208) Full Text
Kamal Awad, Simon Young, Pranesh Aswath, Venu Varanasi, Interfacial adhesion and surface bioactivity of anodized titanium modified with SiON and SiONP surface coatings. Surfaces and Interfaces. NIHMSID: NIHMS1764175. https://doi.org/10.1016/j.surfin.2021.101645. NIHMSID: 1764175. Full Text
Daghrery A, Ferreira JA, Xu J, Golafshan N, Kaigler D, Bhaduri SB, Malda J, Castilho M, Bottino MC. Tissue-specific melt electrowritten polymeric scaffolds for coordinated regeneration of soft and hard periodontal tissues. Bioact Mater. 2022 Apr 22;19:268-281. doi: 10.1016/j.bioactmat.2022.04.013 Full Text
S Shindo, IJ Savitri, T Ishii, A Ikeda, R Pierrelus, A Heidari, K Okubo, S Nakamura, Umadevi Kandalam. Dual-function semaphorin 4D released by platelets: suppression of osteoblastogenesis and promotion of osteoclastogenesis. International journal of molecular sciences, 2022•mdpi.com. 2022, 23(6), 2938; Full Text
Takenobu Ishii , Montserrat Ruiz-Torruella,, Kenta Yamamoto , Tsuguno Yamaguchi , Alireza Heidari , Roodelyne Pierrelus , Elizabeth Leon , Satoru Shindo , Mohamad Rawas-Qalaji , Maria Rita Pastore , Atsushi Ikeda , Shin Nakamura , Hani Mawardi , Umadevi Kandalam , Patrick Hardigan , Lukasz Witek , Paulo G Coelho , Toshihisa Kawai. Locally Secreted Semaphorin 4D Is Engaged in Both Pathogenic Bone Resorption and Retarded Bone Regeneration in a Ligature-Induced Mouse Model of Periodontitis Affiliations expand PMID: 35628440 PMCID: PMC9148012 DOI: 10.3390/ijms23105630. 2022 May 18;23(10):5630. Full Text
Wisanu Boonrawd, Kamal R Awad, Venu Varanasi, Efstathios I Meletis, Surface characteristics and in-vitro studies of TiO2 coatings by plasma electrolytic oxidation in potassium-phosphate electrolyte. Ceramics international. https://doi.org/10.1016/j. ceramint.2021.11.266. NIHMSID: 1762548 Full Text
Young D, Diecidue R, Taub D, Feldman G Development of a Cause-based Treatment for NBP-induced MRONJ Journal of Oral and Maxillofacial Surgery(2021)Volume 79, Issue 10, 2021, e51-e52,ISSN 0278-2391. Full Text
Meer N. Ahmed, MS, DMD, Delin Shi, MS, Matthew T. Dailey, DDS, Kristi Rothermund, BS, HTL(ASCP), Michelle D. Drewry, MS, Tia C. Calabrese, BSE, Xinyan T. Cui, PhD, and Fatima N. Syed-Picard, MSE, PhD. Dental Pulp Cell Sheets Enhance Facial Nerve Regeneration via Local Neurotrophic Factor Delivery. Tissue Engineering, Part A. 27(17-18) (2021). Full Text
Daghrery A, Ferreira JA, de Souza Araújo IJ, Clarkson BH, Eckert GJ, Bhaduri SB, Malda J, Bottino MC. A Highly Ordered, Nanostructured Fluorinated CaP-Coated Melt Electrowritten Scaffold for Periodontal Tissue Regeneration. Adv Healthc Mater. 2021 Nov;10(21):e2101152. doi: 10.1002/adhm.202101152. Full Text
He P, Zhang Q, Motiwala FI, Shanti RM, Chang BM, Le AD. Potential application of dental stem cells in regenerative reconstruction of oral and maxillofacial tissues: a narrative review. Front Oral Maxillofac Med 2021. Full Text
Ahuja N, Awad K, Peper S, Brotto M, Varanasi V. Mini review: Biomaterials in repair and regeneration of nerve in a volumetric muscle loss. Neurosci Lett. 2021 Sep 25;762:136145 Epub 2021 Jul 28. Review. https://doi.org/10.1016/j.neulet.2021.136145. PubMed PMID: 34332029; PubMed Central PMCID: PMC8529875. Full Text
Wisanu Boonrawd, Kamal R Awad, Venu Varanasi, Efstathios I Meletis, Wettability and in-vitro study of titanium surface profiling prepared by electrolytic plasma processing. Surface & coatings technology. NIHMSID: NIHMS1764206. https://doi.org/10.1016/j.surfcoat.2021.127119. NIHMSID: 1764206. Abstract
Drewry, Michelle; Dailey, Matthew; Rothermund, Kristi; Backman, Charles; Dahl, Kris; Syed-Picard, Fatima. Promoting and orienting axon extension using scaffold-free dental pulp stem cell sheets. ACS Biomaterials Science & Engineering, 19 Aug 2021. Submitted for publication. Full Text
Anderson M, Dubey N, Bogie K, Cao C, Li J, Lerchbacker J, Mendonça G, Kauffmann F, Bottino MC, Kaigler D. Three-dimensional printing of clinical scale and personalized calcium phosphate scaffolds for alveolar bone reconstruction. Dent Mater. 2022 Mar;38(3):529-539. doi: 10.1016/j.dental.2021.12.141. Full Text
Dubey N, Ferreira JA, Malda J, Bhaduri SB, Bottino MC. Extracellular Matrix/Amorphous Magnesium Phosphate Bioink for 3D Bioprinting of Craniomaxillofacial Bone Tissue. ACS Appl Mater Interfaces. 2020 May 27;12(21):23752-23763. doi: 10.1021/acsami.0c05311. Full Text
Dubey N, Ferreira JA, Daghrery A, Aytac Z, Malda J, Bhaduri SB, Bottino MC. Highly tunable bioactive fiber-reinforced hydrogel for guided bone regeneration. Acta Biomater. 2020 Sep 1;113:164-176. doi: 10.1016/j.actbio.2020.06.011. Full Text
Sikder P, Ferreira JA, Fakhrabadi EA, Kantorski KZ, Liberatore MW, Bottino MC, Bhaduri SB. Bioactive amorphous magnesium phosphate-polyetheretherketone composite filaments for 3D printing. Dent Mater. 2020 Jul;36(7):865-883. doi: 10.1016/j.dental.2020.04.008. Full Text
Wofford A, Bow A, Newby S, Brooks S, Rodriguez R, Masi T, Stephenson S, Gotcher J, Anderson DE, Campbell J, Dhar M. Human Fat-Derived Mesenchymal Stem Cells Xenogenically Implanted in a Rat Model Show Enhanced New Bone Formation in Maxillary Alveolar Tooth Defects. Stem Cells Int. 2020 Jan 13;2020:8142938. doi: 10.1155/2020/8142938. eCollection 2020.PMID: 32399052. Full Text
Piotrowski SL, Wilson L, Maldonado KL, Tailor R, Hill LR, Bankson JA, Lai S, Kasper FK, Young S: Effect of Radiation on DCE-MRI Pharmacokinetic Parameters in a Rabbit Model of Compromised Maxillofacial Wound Healing: A Pilot Study. J Oral Maxillofac Surg, 78(6):1034.e1-1034.e10, 2020. Full Text
M. Omidi, L. Almeida, L. Tayebi Microfluidic-assisted fabrication of reverse micelle /PLGA hybrid microspheres for sustained vascular endothelial growth factor delivery Biotechnology and Applied Biochemistry, DOI: 10.1002/bab.1971(2020). Full Text
E. Watson, A.M. Tatara, J.J.J.P. van den Beucken, J.A. Jansen, M.E. Wong, and A.G. Mikos, “An Ovine Model of In Vivo Bioreactor-Based Bone Generation,” Tissue Eng. Part C: Methods, in press. 15 Jul 2020 https://doi.org/10.1089/ten.tec.2020.0125. Full Text
E. Dashtimoghadam, F. Fahimipour, N. Tongus, L. Tayebi Microfluidic Fabrication of Microcarriers with Sequential Delivery of VEGF and BMP-2 for Bone Regeneration Scientific Reports, Sci Rep 10, 11764. DOI:10.1038/s41598-020-68221-w (2020). Full Text
JAGGED1 stimulates cranial neural crest cell osteoblast commitment pathways and bone regeneration independent of canonical NOTCH signaling Archana Kamalakar 1, Jay M McKinney 2, Daniel Salinas Duron 3, Angelica M Amanso 4, Samir A Ballestas 5, Hicham Drissi 6, Nick J Willett 7, Pallavi Bhattaram 8, Andrés J García 9, Levi B Wood 10, Steven L Goudy 11 PMID: 32980561. DOI: 10.1016/j.bone.2020.115657. Full Text
E. Watson, B.T. Smith, M.M. Smoak, A.M. Tatara, S.R. Shah, H.A. Pearce, K.J. Hogan, J. Shum, J. Melville, I. Hanna, N. Demian, J.C. Wenke, G.N. Bennett, J.J.J.P. van den Beucken, J.A. Jansen, M.E. Wong, and A.G. Mikos, “Localized Mandibular Infection Affects Remote In Vivo Bioreactor Bone Generation,” Biomaterials, in press. Volume 256, October 2020, 120185. Full Text
Jay P. Malmquist, Todd Scantlebury, R. Gilbert Triplett. Osteo Science Foundation Collagen White Paper, 2019. Full Text
Wang X., Lin M., and Kang Y. Engineering Porous β-Tricalcium Phosphate (β-TCP) Scaffolds with Multiple Channels to Promote Cell Migration, Proliferation, and Angiogenesis. ACS Applied Materials & Interfaces 2019 11 (9), 9223-9232. DOI: 10.1021/acsami.8b22041. Full Text
Alexander M. Tatara, Gerry L. Koons, Emma Watson, Trenton C.Piepergerdes, Sarita R. Shah, Brandon T. Smith, Jonathan Shum, James C.Melville, Issa A. Hanna, Nagi Demian, Tang Ho, Anthony Ratcliffe, Jeroen J. J. P. van den Beucken, John A. Jansen, Mark E. Wong, Antonios G. Mikos. Biomaterials-aided mandibular reconstruction using in vivo bioreactors. Proceedings of the National Academy of Sciences Mar 2019, 201819246; DOI:10.1073/pnas.1819246116. Full Text
Piotrowski SL, Wilson L, Dharmaraj N, Hamze A, Clark A, Tailor R, Hill L, Lai S, Kasper K, and Young S: Development and Characterization of a Rabbit Model of Compromised Maxillofacial Wound Healing. Tissue Eng Part C Methods, 25(3):160-167, 2019. Full Text
Charbonnier B, Baradaran A, Sato D, Alghamdi O, Zhang Z, Zhang YL, Gbureck U, Gilardino M, Harvey E, Makhoul N, Barralet J. Material-Induced Venosome- Supported Bone Tubes. Adv Sci (Weinh). 2019 Jul 1;6(17):1900844. doi: 10.1002/advs.201900844. PMID: 31508287; PMCID: PMC6724474. Full Text
Yagnik A, Feldman G, Diecidue R, Taub D Development of a Cause Based Treatment for Nitrogen Containing Bisphosphonate Induced MRONJ J Oral and Maxillofacial Surgery 2019;77: supplement e44-e45.). Full Text
Lobat Tayebi, Meisam Omidi, Mohadeseh Hashemi, Microfluidic synthesis of PLGA/carbon quantum dot microspheres for vascular endothelial growth factor delivery. Oct 2019. Full Text
Zhang QZ, Chen C, Chang MB, Shanti RM, Cannady SB, O’Malley BW, Shi S, Le AD. Oral Rehabilitation of Patients Sustaining Orofacial Injuries: The UPenn Initiative. Adv Dent Res. 2019;30(2):50‐56. doi:10.1177/0022034519877400. Full Text
Mao Q, Nguyen PD, Shanti RM, Shi S, Shakoori P, Zhang Q, Le AD. Gingiva-Derived Mesenchymal Stem Cell-Extracellular Vesicles Activate Schwann Cell Repair Phenotype and Promote Nerve Regeneration. Tissue Eng Part A. 2019 Jun;25(11-12):887-900. doi: 10.1089/ten.TEA.2018.0176. Epub 2018 Dec 28. PMID: 30311853. Full Text
Zhang Y, Shi S, Xu Q, Zhang Q, Shanti RM, Le AD. SIS-ECM Laden with GMSC-Derived Exosomes Promote Taste Bud Regeneration. J Dent Res. 2019;98(2):225‐233. doi:10.1177/0022034518804531.Full Text
Zhang Q, Nguyen PD, Shi S, Burrell JC, Xu Q, Cullen KD, Le AD. Neural Crest Stem-Like Cells Non-genetically Induced from Human Gingiva-Derived Mesenchymal Stem Cells Promote Facial Nerve Regeneration in Rats. Mol Neurobiol. 2018 Jan 25. doi: 10.1007/s12035-018-0913-3. [Epub ahead of print] PMID: 29372546 Full Text
Kaplan HM. Regulating non-viable tissue. Chapter. Section: Regulatory pathways and barriers to implementation of tissue engineering and regenerative medicine. Richmond FJ, Section ed. In: Warburton D, ed. “Encyclopedia of Tissue Engineering and Regenerative Medicine”. USA: Elsevier. In Press, Apr 2018. Abstract
Qunzhou Zhang, Phuong Nguyen, Shihong Shi, Justin Burrell, Kacy Cullen, Anh D. Le. 3D Bioprinted Scaffold-free Nerve Constructs with Human Gingiva-derived Mesenchymal Stem Cells as Bioink Promote Rat Facial Nerve Regeneration. Scientific Reportsvolume 8, Article number: 6634 (2018) Full Text
Jazayeri, H. E.; Dorafshar, A. H. “Engineering a New Era: Will Autogenous Tissue Remain the Gold Standard for Head and Neck Reconstruction?”, Journal of Oral and Maxillofacial Surgery, published online: 2018. Full Text
Kang Y. Chang J. Channels in a porous scaffold: a new player for vascularization. Future Medicine. Regenerative Medicine, Vol. 13, No. 6. Online, 24 Sep 2018. Full Text
AM Emmakah1, 4, HE Arman2, JC Bragg3, T Greene3, MB Alvarez2, PJ Childress2, WS Goebel4,MA Kacena2, CC Lin1, 3, and TM Chu. A Fast-Degrading Thiol-Acrylate based Hydrogel for Cranial Regeneration, Journal of Biomaterials., at press: 2017. Full Text
Cai X, Ten Hoopen S, Zhang W, Yi C, Yang W, Yang F, Jansen JA, Walboomers XF, Yelick PC. Influence of highly porous electrospun PLGA/PCL/nHA fibrous scaffolds on the differentiation of tooth bud cells in vitro. J Biomed Mater Res A. 2017 Sep;105(9):2597-2607. doi: 10.1002/jbm.a.36120. Epub 2017 Jun 15. PMID: 28544201; PMCID: PMC5695215. Full Text
Jiabing Fan, Joan Pi-Anfruns, Mian Guo, Dan C. S. Im, Zhong-Kai Cui, Soyon Kim, Benjamin M. Wu, Tara L. Aghaloo & Min Lee. Small molecule-mediated tribbles homolog 3 promotes bone formation induced by bone morphogenetic protein-2. Scientific Reports, published online: 2017. Full Text
Zhang Q, Nguyen P, Xu Q, Park W, Lee S, Furuhashi A, Le AD. Neural Progenitor-Like Cells Induced from Human Gingiva-Derived Mesenchymal Stem Cells Regulate Myelination of Schwann Cells in Rat Sciatic Nerve Regeneration. Stem Cells Transl Med. 2017 Feb;6(2):458-470. doi: 10.5966/sctm.2016-0177 PMID: 27604215. Full Text
Han, Z.; Trout, W. S.; Liu, S.; Andrade, G. A.; Hudson, D. A.; Scinto, S. L.; Dicker, K. T.; Li, Y.; Lazouski, N.; Rosenthal, J.; Thorpe, C; Jia, X.; Fox, J. M. “Rapid Bioorthogonal Chemistry Turn–on through Enzymatic or Long Wavelength Photocatalytic Activation of Tetrazine Ligation”, J. Am. Chem. Soc. 2016, 38, 5978–5983. Full Text
Zhang W, Zhang Z, Chen S, Macri L, Kohn J, Yelick PC. “Mandibular Jaw Bone Regeneration Using Human Dental Cell-Seeded Tyrosine-Derived Polycarbonate Scaffolds” Tissue Eng Part A. 2016 Jul;22(13-14):985-93. doi: 10.1089/ten.TEA.2016.0166. PMID: 27369635; PMCID: PMC4985268. Full Text
Ravikrishnan, A.; Ozdemir, T.; Bah, M.; Baskerville, K. A.; Shah, S. I.; Ayyappan, R. K.; Jia, X. “Regulation of Epithelial–to–Mesenchymal Transition Using Biomimetic Fibrous Scaffolds” ACS Appl. Mater. Interfaces 2016, DOI: 10.1021/acsami.6b05646. Full Text
A.M. Tatara, S.R. Shah, N. Demian, T. Ho, J. Shum, J.J.J.P. van den Beucken, J.A. Jansen, M.E. Wong, and A.G. Mikos, “Reconstruction of Large Mandibular Defects Using Autologous Tissues Generated From In Vivo Bioreactors,” Acta Biomaterialia, 45, 72-84 (2016). DOI:10.1016/j.actbio.2016.09.013 Full Text
AM Tatara, SR Shah, E Watson, BT Smith, N Demian, IA Hanna, JC Melville, J Shum, T Ho, JJ van den Beucken, JA Jansen, ME Wong, AG Mikos “Ovine Model For Generation of Tissue-Engineered Vascularized Bone of Large Volume and Custom Geometry” Tissue Engineering Part A (22). 2016, Dec; S155-156 Full Text
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