Research Publications


Wofford A, Bow A, Newby S, Brooks S, Rodriguez R, Masi T, Stephenson S, Gotcher J, Anderson DE, Campbell J, Dhar M. Human Fat-Derived Mesenchymal Stem Cells Xenogenically Implanted in a Rat Model Show Enhanced New Bone Formation in Maxillary Alveolar Tooth Defects. Stem Cells Int. 2020 Jan 13;2020:8142938. doi: 10.1155/2020/8142938. eCollection 2020.PMID: 32399052. Full Text

Piotrowski SL, Wilson L, Maldonado KL, Tailor R, Hill LR, Bankson JA, Lai S, Kasper FK, Young S: Effect of Radiation on DCE-MRI Pharmacokinetic Parameters in a Rabbit Model of Compromised Maxillofacial Wound Healing: A Pilot Study. J Oral Maxillofac Surg, 78(6):1034.e1-1034.e10, 2020. Full Text

M. Omidi, L. Almeida, L. Tayebi Microfluidic-assisted fabrication of reverse micelle /PLGA hybrid microspheres for sustained vascular endothelial growth factor delivery Biotechnology and Applied Biochemistry, DOI: 10.1002/bab.1971(2020). Full Text

E. Watson, A.M. Tatara, J.J.J.P. van den Beucken, J.A. Jansen, M.E. Wong, and A.G. Mikos, “An Ovine Model of In Vivo Bioreactor-Based Bone Generation,” Tissue Eng. Part C: Methods, in press. 15 Jul 2020 Full Text

E. Dashtimoghadam, F. Fahimipour, N. Tongus, L. Tayebi Microfluidic Fabrication of Microcarriers with Sequential Delivery of VEGF and BMP-2 for Bone Regeneration Scientific Reports, Sci Rep 10, 11764. DOI:10.1038/s41598-020-68221-w (2020). Full Text

JAGGED1 stimulates cranial neural crest cell osteoblast commitment pathways and bone regeneration independent of canonical NOTCH signaling Archana Kamalakar 1, Jay M McKinney 2, Daniel Salinas Duron 3, Angelica M Amanso 4, Samir A Ballestas 5, Hicham Drissi 6, Nick J Willett 7, Pallavi Bhattaram 8, Andrés J García 9, Levi B Wood 10, Steven L Goudy 11 PMID: 32980561. DOI: 10.1016/j.bone.2020.115657. Full Text

E. Watson, B.T. Smith, M.M. Smoak, A.M. Tatara, S.R. Shah, H.A. Pearce, K.J. Hogan, J. Shum, J. Melville, I. Hanna, N. Demian, J.C. Wenke, G.N. Bennett, J.J.J.P. van den Beucken, J.A. Jansen, M.E. Wong, and A.G. Mikos, “Localized Mandibular Infection Affects Remote In Vivo Bioreactor Bone Generation,” Biomaterials, in press. Volume 256, October 2020, 120185. Full Text


Jay P. Malmquist, Todd Scantlebury, R. Gilbert Triplett. Osteo Science Foundation Collagen White Paper, 2019. Full Text

Wang X., Lin M., and Kang Y. Engineering Porous β-Tricalcium Phosphate (β-TCP) Scaffolds with Multiple Channels to Promote Cell Migration, Proliferation, and Angiogenesis. ACS Applied Materials & Interfaces 2019 11 (9), 9223-9232. DOI: 10.1021/acsami.8b22041. Full Text

Alexander M. Tatara, Gerry L. Koons, Emma Watson, Trenton C.Piepergerdes, Sarita R. Shah, Brandon T. Smith, Jonathan Shum, James C.Melville, Issa A. Hanna, Nagi Demian, Tang Ho, Anthony Ratcliffe, Jeroen J. J. P. van den Beucken, John A. Jansen, Mark E. Wong, Antonios G. Mikos. Biomaterials-aided mandibular reconstruction using in vivo bioreactors. Proceedings of the National Academy of Sciences Mar 2019, 201819246; DOI:10.1073/pnas.1819246116. Full Text

Piotrowski SL, Wilson L, Dharmaraj N, Hamze A, Clark A, Tailor R, Hill L, Lai S, Kasper K, and Young S: Development and Characterization of a Rabbit Model of Compromised Maxillofacial Wound Healing. Tissue Eng Part C Methods, 25(3):160-167, 2019. Full Text

Charbonnier B, Baradaran A, Sato D, Alghamdi O, Zhang Z, Zhang YL, Gbureck U, Gilardino M, Harvey E, Makhoul N, Barralet J. Material-Induced Venosome- Supported Bone Tubes. Adv Sci (Weinh). 2019 Jul 1;6(17):1900844. doi: 10.1002/advs.201900844. PMID: 31508287; PMCID: PMC6724474. Full Text

Yagnik A, Feldman G, Diecidue R, Taub D Development of a Cause Based Treatment for Nitrogen Containing Bisphosphonate Induced MRONJ J Oral and Maxillofacial Surgery 2019;77: supplement e44-e45.). Full Text

Lobat Tayebi,

Zhang QZ, Chen C, Chang MB, Shanti RM, Cannady SB, O’Malley BW, Shi S, Le AD. Oral Rehabilitation of Patients Sustaining Orofacial Injuries: The UPenn Initiative. Adv Dent Res. 2019;30(2):50‐56. doi:10.1177/0022034519877400. Full Text

Mao Q, Nguyen PD, Shanti RM, Shi S, Shakoori P, Zhang Q, Le AD. Gingiva-Derived Mesenchymal Stem Cell-Extracellular Vesicles Activate Schwann Cell Repair Phenotype and Promote Nerve Regeneration. Tissue Eng Part A. 2019 Jun;25(11-12):887-900. doi: 10.1089/ten.TEA.2018.0176. Epub 2018 Dec 28. PMID: 30311853. Full Text 


Zhang Q, Nguyen PD, Shi S, Burrell JC, Xu Q, Cullen KD, Le AD. Neural Crest Stem-Like Cells Non-genetically Induced from Human Gingiva-Derived Mesenchymal Stem Cells Promote Facial Nerve Regeneration in Rats. Mol Neurobiol. 2018 Jan 25. doi: 10.1007/s12035-018-0913-3. [Epub ahead of print] PMID: 29372546 Full Text

Kaplan HM. Regulating non-viable tissue. Chapter. Section: Regulatory pathways and barriers to implementation of tissue engineering and regenerative medicine. Richmond FJ, Section ed. In: Warburton D, ed. “Encyclopedia of Tissue Engineering and Regenerative Medicine”. USA: Elsevier. In Press, Apr 2018.

Kaplan HM. Regulating non-viable tissue. Elsevier Reference Module in Biomedical Sciences. USA: Elsevier Online. In Press, Apr 2018.

Qunzhou Zhang, Phuong Nguyen, Shihong Shi, Justin Burrell, Kacy Cullen, Anh D. Le. 3D Bioprinted Scaffold-free Nerve Constructs with Human Gingiva-derived Mesenchymal Stem Cells as Bioink Promote Rat Facial Nerve Regeneration. Scientific Reportsvolume 8, Article number: 6634 (2018) Full Text

Jazayeri, H. E.; Dorafshar, A. H. “Engineering a New Era: Will Autogenous Tissue Remain the Gold Standard for Head and Neck Reconstruction?”, Journal of Oral and Maxillofacial Surgery, published online: 2018. Full Text

Kang Y. Chang J. Channels in a porous scaffold: a new player for vascularization. Future Medicine. Regenerative Medicine, Vol. 13, No. 6. Online, 24 Sep 2018. Full Text

Zhang Y, Shi S, Xu Q, Zhang Q, Shanti RM, Le AD. SIS-ECM Laden with GMSC-Derived Exosomes Promote Taste Bud Regeneration. J Dent Res. 2019;98(2):225‐233. doi:10.1177/0022034518804531. Full Text


AM Emmakah1, 4, HE Arman2, JC Bragg3, T Greene3, MB Alvarez2, PJ Childress2, WS Goebel4,MA Kacena2, CC Lin1, 3, and TM Chu. A Fast-Degrading Thiol-Acrylate based Hydrogel for Cranial Regeneration, Journal of Biomaterials., at press: 2017. Full Text

Cai X, Ten Hoopen S, Zhang W, Yi C, Yang W, Yang F, Jansen JA, Walboomers XF, Yelick PC. Influence of highly porous electrospun PLGA/PCL/nHA fibrous scaffolds on the differentiation of tooth bud cells in vitro. J Biomed Mater Res A. 2017 Sep;105(9):2597-2607. doi: 10.1002/jbm.a.36120. Epub 2017 Jun 15. PMID: 28544201; PMCID: PMC5695215. Full Text 

Jiabing Fan, Joan Pi-Anfruns, Mian Guo, Dan C. S. Im, Zhong-Kai Cui, Soyon Kim, Benjamin M. Wu, Tara L. Aghaloo & Min Lee. Small molecule-mediated tribbles homolog 3 promotes bone formation induced by bone morphogenetic protein-2. Scientific Reports, published online: 2017. Full Text


Han, Z.; Trout, W. S.; Liu, S.; Andrade, G. A.; Hudson, D. A.; Scinto, S. L.; Dicker, K. T.; Li, Y.; Lazouski, N.; Rosenthal, J.; Thorpe, C; Jia, X.; Fox, J. M. “Rapid Bioorthogonal Chemistry Turn–on through Enzymatic or Long Wavelength Photocatalytic Activation of Tetrazine Ligation”, J. Am. Chem. Soc. 2016, 38, 5978–5983. 

Zhang Q, Nguyen P, Xu Q, Park W, Lee S, Furuhashi A, Le AD. Neural Progenitor-Like Cells Induced from Human Gingiva-Derived Mesenchymal Stem Cells Regulate Myelination of Schwann Cells in Rat Sciatic Nerve Regeneration. Stem Cells Transl Med. 2017 Feb;6(2):458-470. doi: 10.5966/sctm.2016-0177 PMID: 27604215.

Zhang W, Zhang Z, Chen S, Macri L, Kohn J, Yelick PC. “Mandibular Jaw Bone Regeneration Using Human Dental Cell-Seeded Tyrosine-Derived Polycarbonate Scaffolds” Tissue Eng Part A. 2016 Jul;22(13-14):985-93. doi: 10.1089/ten.TEA.2016.0166. PMID: 27369635; PMCID: PMC4985268. Full Text 

Ravikrishnan, A.; Ozdemir, T.; Bah, M.; Baskerville, K. A.; Shah, S. I.; Ayyappan, R. K.; Jia, X. “Regulation of Epithelial–to–Mesenchymal Transition Using Biomimetic Fibrous Scaffolds” ACS Appl. Mater. Interfaces 2016, DOI: 10.1021/acsami.6b05646. Full Text

A.M. Tatara, S.R. Shah, N. Demian, T. Ho, J. Shum, J.J.J.P. van den Beucken, J.A. Jansen, M.E. Wong, and A.G. Mikos, “Reconstruction of Large Mandibular Defects Using Autologous Tissues Generated From In Vivo Bioreactors,” Acta Biomaterialia, 45, 72-84 (2016). DOI:10.1016/j.actbio.2016.09.013  Full Text

AM Tatara, SR Shah, E Watson, BT Smith, N Demian, IA Hanna, JC Melville, J Shum, T Ho, JJ van den Beucken, JA Jansen, ME Wong, AG Mikos “Ovine Model For Generation of Tissue-Engineered Vascularized Bone of Large Volume and Custom Geometry” Tissue Engineering Part A (22). 2016, Dec; S155-156 Full Text


Ruggiero L, Zimmerman BK, Park M, Han L, Wang L, Burris DL, Lu XL. Roles of the Fibrous Superficial Zone in the Mechanical Behavior of TMJ Condylar Cartilage. Annals of biomedical engineering. 2015; PMID: 25893511  Abstract






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