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American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies

American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies

Cell-based therapies for restoration of tissue structure and function attract considerable attention presently, due in part to the prevalence of anecdotal reports in the literature, patient testimonials, and direct-to-consumer marketing. However, realization of the full potential of cell-based therapies toward advancing patient care ultimately depends upon rigorous scientific investigation and appropriate tempering of patient expectations. A recent report from a Joint Task Force of the American Society for Bone and Mineral Research and the Orthopaedic Research Society focuses on defining the state-of-the-art in cell-based therapies and identifying appropriate target areas for future investigation, with a particular focus on musculoskeletal tissues. The report summarizes findings in key areas, including cellular sources, cell-derived products, tissue-specific animal models, outcomes assessment, and ethical considerations in the context of cell-based therapies for musculoskeletal repair. Overall, the group concludes that outcomes of cell-based therapies are highly variable and that the therapies should be considered experimental at present. While the report focuses on musculoskeletal repair, the themes of the article clearly extend to future directions for cell-based therapies in craniofacial tissue repair.

Citation Information:

O’Keefe RJ, Tuan RS, Lane NE, Barry F, Bunnell BA, Colnot C, Drake MT, Drissi H, Fortier LA, Guldberg RE, Little DG, Marshall MF, Mao JJ, Nakamura N, Robey PG, Rosen V, Rowe DW, Schwarz EM. J Bone Miner Res. 2019. doi: 10.1002/jbmr.3839.

PMID: 31545883

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