An engineered cell-laden adhesive hydrogel promotes craniofacial bone tissue regeneration in rats
Hasani-Sadrabadi MM, Sarrion P, Pouraghaei S, Chau Y, Ansari S, Li S, Aghaloo T, Moshaverinia A
Sci Transl Med. 2020 Mar 11;12(534). pii: eaay6853. doi: 10.1126/scitranslmed.aay6853.
Some strategies for craniofacial bone regeneration leverage injectable hydrogel materials as carriers of osteogenic cell populations to promote bone formation. However, achieving suitable adhesion of the hydrogel to surrounding tissues often presents a challenge in aqueous environments, such as the oral cavity. A recent article by Hasani-Sadrabadi et al. reports an injectable, biodegradable hydrogel system incorporating chemical moieties inspired by murine mussels to promote tissue adhesion in an aqueous environment. The study included investigation of the hydrogel system as a therapeutic cell delivery vehicle in a rat model of peri-implantitis. The authors demonstrated incorporation of osteoconductive hydroxyapatite microparticles and aggregates of gingival mesenchymal stems cells within the hydrogels, which supported bone formation in an ectopic murine subcutaneous implantation site. Additional study of the material demonstrated adhesion to rat gingiva, rat calvaria and periosteum, and the root surfaces of extracted human teeth. The authors applied the hydrogel constructs in a rat model of peri-implantitis and observed bone regeneration around titanium implants over the course of 8 weeks. Overall, the article reports an innovative injectable hydrogel system capable of adhesion to tissues in an aqueous environment for local delivery and retention of osteogenic cells in strategies for craniofacial bone regeneration.