Author: Andrea Boidman

Large mandibular defects are clinically challenging to reconstruct due to the complex anatomy of the jaw and the limited availability of appropriate tissue for repair. We envision leveraging current advances in fabrication and biomaterials to create implantable devices that generate bone within the patients themselves suitable for their own specific anatomical pathology. 

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Engineering strategies to facilitate regeneration of missing tissues commonly employ biomaterial scaffolds to guide tissue formation. Such approaches often seek to leverage bioresorbable scaffold materials to mitigate potential complications that might be associated with long-term retention of the implanted material.

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Inadequate oxygen and nutrient diffusion in a porous scaffold often resulted in insufficient formation of branched vasculatures, which hindered bone regeneration. In this study, interconnected porous β-tricalcium phosphate (β-TCP) scaffolds with different geometric designs of channels were fabricated and compared to discover the functionality of structure on facilitating nutrient diffusion for angiogenesis. In vitro fluid […]

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Defects in the maxillofacial skeleton often present with a compromised wound bed and associated challenges to repair. However, pre-clinical investigation of tissue engineering and regenerative medicine strategies seeking to facilitate repair of such defects commonly involves a healthy animal model presenting an ideal wound bed.

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The growth of the field of tissue engineering over the past several decades has been remarkable. While considerable investments continue to be placed in research and development for tissue engineering technologies, translation of the technologies to the clinic to effect patient care remains the ultimate objective.

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Autograft bone serves as a standard option for bone regeneration in a variety of contexts in the craniomaxillofacial complex, due in part to the osteoinductivity generally presented by the graft tissue. Nonetheless, the limited availability of autograft bone, patient morbidity, and other considerations motivate the development of autograft extenders to reduce the volume required to […]

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Two doctors performing oral surgery on patients

Leading the Way Through Education

Knowledge. Practical Skills. Collaboration. We know these are among the essential building blocks to move our industry and its practitioners forward.  At Osteo Science Foundation, we are expanding our research and impact by spearheading a wide variety of leading educational initiatives. Osteo Science Foundation is committed to delivering the highest standard of education for our […]

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Research Accomplishments

Research drives progress. That’s why Osteo Science Foundation is committed to supporting the next generation of scientists in their pursuit of high-quality research. Our researchers are making significant strides forward. Their work strengthens our field and brings the hop of better medicine that much closer. We are proud to be their partners and to help […]

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Tissue engineering is based on the interaction between stem cells, biomaterials and factors delivered in biological niches. Oral tissues have been found to be rich in stem cells from different sources: Stem cells from oral cavity are easily harvestable and have shown a great plasticity towards the main lineages, specifically towards bone tissues.

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