Author: Ashley_admin

Regeneration of large volumes of bone with biomaterial-based strategies remains a considerable challenge due in part to the need for vascular support of the regenerating tissue. The complexity of the challenge increases when the biomaterials serve as carriers of cell populations envisioned to promote bone formation.  

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A variety of bone graft products have been developed to provide alternatives to autologous bone to fill bony defects. The pathway to clinical translation of bone graft materials typically involves pre-clinical studies in cell culture followed by evaluation of safety and efficacy in pre-clinical animal models. 

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Advances In Regenerative Medicine Article Image
Scaffold-based approaches for bone regeneration often incorporate biologically active factors to facilitate desired outcomes, including bone formation and vascularization. Literature over the years suggests that magnesium may present osteogenic and angiogenic potential in certain contexts, which might be leveraged in regenerative medicine approaches to bone tissue repair.  

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Volumetric muscle defects, such as those associated with cleft lip, often require multiple surgeries to repair, and the outcomes may be limited in terms of function and cosmesis. While tissue engineering strategies are being explored to facilitate repair of volumetric muscle defects in pre-clinical models, the models typically involve muscles in the extremities that do […]

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