Osteo Science Foundation is all about advancing regenerative medicine in Oral and CranioMaxillofacial Surgery. We have compiled articles from within the OMFS field that share new and exciting developments and techniques in regenerative medicine. Some are already in clinical practice and some are decades away; but all show how the dial is moving forward in the quest for better patient care through regenerative medicine. We also feature articles from journals from disciplines outside OMFS, to bring your relevant regenerative news that, while not necessarily focused in OMFS, is relevant to the OMFS field.
In addition, all articles that have resulted from research funded by Osteo Science Foundation are also listed below: these are among our greatest contributions to the field of regenerative medicine and we are proud to add them to this library.
To stay updated on Advances in Regenerative Medicine, follow us on Facebook, LinkedIn, and Instagram, where our regular feature, "Exploration Tuesday" highlights an Advance in Regenerative Medicine.
Loss of alveolar bone after tooth extraction has motivated development of a variety of approaches for alveolar ridge preservation.
Tissue engineering and regenerative medicine approaches harness knowledge of cell populations and the factors that direct cellular function to inform tissue formation.
Microvascular transfer of autologous muscle provides an option for facial reanimation in some cases of facial nerve palsy and for the treatment of certain craniofacial muscle defects.
Emerging bioprinting technologies enable fabrication of constructs for tissue engineering with spatially controlled deposition of cells and biologically active factors to mimic the structural complexity of tissues.
The mechanical strength of metallic biomaterials supports their application in the fabrication of bone fixation plates and in development of scaffolds for bone tissue engineering.
Autografts and allografts are commonly applied in the surgical treatment of craniofacial bone defects, but limitations associated with each have motivated the development of alloplastic graft materials capable of supporting bone tissue regeneration.
Many investigations in recent years have applied injectable hydrogels as carriers for biologically active factors and as cell transplant vehicles for bone tissue regeneration.
The emergence of bioprinting technologies in recent years presents exceptional promise to enable fabrication of patient-specific three-dimensional constructs for tissue engineering and regenerative medicine applications.
Realization of complex three-dimensional structures associated with solid organs through bioprinting approaches presents considerable technical challenges.
Advances in medical imaging and 3D printing technologies inspire exceptional interest in the fabrication of patient-specific biomaterial-based grafts to support craniofacial bone regeneration, especially in large volume defects.
Regeneration of large volumes of bone with biomaterial-based strategies remains a considerable challenge due in part to the need for vascular support of the regenerating tissue.
A variety of bone graft products have been developed to provide alternatives to autologous bone to fill bony defects. The pathway to clinical translation of bone graft materials typically involves pre-clinical studies in cell culture followed by evaluation of safety and efficacy in pre-clinical animal models.
Scaffold-based approaches for bone regeneration often incorporate biologically active factors to facilitate desired outcomes, including bone formation and vascularization. Literature over the years suggests that magnesium may present osteogenic and angiogenic potential in certain contexts, which might be leveraged in regenerative medicine approaches to bone tissue repair.
Volumetric muscle defects, such as those associated with cleft lip, often require multiple surgeries to repair, and the outcomes may be limited in terms of function and cosmesis.
Bone regeneration strategies can include the delivery of multiple therapeutic factors to promote tissue formation.
Biomaterial-based approaches to facilitate alveolar bone regeneration remain a focus for investigation owing to the importance of bone of sufficient quantity and quality to support surgically placed dental implants.
Many research studies aim to develop biomaterial scaffolds for craniofacial bone tissue regeneration.
Engineering strategies to facilitate regeneration of missing tissues commonly employ biomaterial scaffolds to guide tissue formation. Such approaches often seek to leverage bioresorbable scaffold materials to mitigate potential complications that might be associated with long-term retention of the implanted material.
Tissue engineering scaffolds increasingly seek to mimic complex biomolecular and mechanical gradients reflective of the tissue(s) of interest to guide regeneration, especially at complex tissue interfaces such as the osteochondral interface of the mandibular condyle.
Emerging modular tissue engineering approaches seek to enable the generation of large-scale tissues from the assembly or fusion of small-scale cellular constructs generated in culture. While modular tissue engineering approaches present advantages with respect to maintaining cell viability in culture prior to assembly of the building blocks, generation of modular constructs with suitable mechanical properties for load-bearing bone regeneration presents a challenge.
The growth of the field of tissue engineering over the past several decades has been remarkable. While considerable investments continue to be placed in research and development for tissue engineering technologies, translation of the technologies to the clinic to effect patient care remains the ultimate objective.
Autograft bone serves as a standard option for bone regeneration in a variety of contexts in the craniomaxillofacial complex, due in part to the osteoinductivity generally presented by the graft tissue.
Tissue engineering is based on the interaction between stem cells, biomaterials and factors delivered in biological niches.
The potential impacts of 3D printing in medicine appear to be remarkable, but regulatory pathways associated with the clinical translation of devices and products produced through 3D printing struggle to maintain pace with the rapidly evolving technologies.
Tissue-engineered cartilage substitutes, which induce the process of endochondral ossification, represent a regenerative strategy for bone defect healing.
Adult mouse skeletal stem cells in the jaw revert to a more developmentally flexible state when called upon to regenerate large portions of bone and tissue, according to a study by researchers at the Stanford University School of Medicine.
In patients with compromised health, bone repair and remodeling present a clinical challenge for orthopedic surgeons, with the most common complication being non-union.
Regenerative surgical procedures have long been considered a suitable method for restoring lost periodontal structure and functional attachment. But how did the concept develop? And what can we expect in the future?
The goal of a surgical procedure aimed at treating multiple recessions is to achieve complete root coverage that blends with the surrounding soft-tissue and ensures long-term stability with a sulcus depth no greater than 2 mm. The current, most commonly used techniques for treating multi-tooth recessions can be divided into two groups:
Bone tissue engineering (BTE) is a developing field in materials science and bioengineering, in which researchers aim to engineer an ideal, bioinspired material to promote assisted bone repair.
Tooth loss is a significant health issue currently affecting millions of people worldwide.
One important aim of the field of tissue engineering (TE) is to replace degenerated tissues with cells and scaffolds that restore tissue function and mediate regeneration.
Mexico has become a groundbreaker in regenerative medical science. And one institution is touting innovative ways to reduce the prohibitive costs of the therapy. CGTN’s Alasdair Baverstock reports.
The species of simple animal known as Planaria has acted as a model organism in the disciplines of tissue regeneration science for quite a while now.
Oral and maxillofacial surgeons at The University of Texas Health Science Center at Houston (UTHealth) have developed and successfully tested a new surgical technique that could be a critical step toward using bioengineered cartilage to treat temporomandibular joint (TMJ) dysfunction.
Facial skin injuries can present exceptional challenges for wound repair considering the complexities of the contours of the face and facial movements.
The study of robotics has been known to yield benefits for humans in a variety of ways; however, a new research study suggests possible benefits but on a different scale.
A major hurdle to using neural stem cells derived from genetically different donors to replace damaged or destroyed tissues, such as in a spinal cord injury, has been the persistent rejection of the introduced material (cells), necessitating the use of complex drugs and techniques to suppress the host’s immune response.
Cardiovascular regeneration focuses on repairing or replacing damaged or senescent cardiac and vascular tissue.
Regenerative medicine is a branch of translational research in tissue engineering and molecular biology which deals with the process of replacing, engineering or regenerating human cells, tissues or organs to restore or establish normal function.
A Purdue University-affiliated startup has devised a way to map arteries in the roof of a person’s mouth to help avoid complications and improve outcomes in oral surgery.
Geistlich invested heavily to develop its latest product, the 3D collagen matrix Geistlich Fibro-Gide®. Dr. Terance Hart, Director Research, and Dr. Mark Spilker, Chief Scientific Officer, talk about innovation, research pathways and strategic collaborations.
Robert E. Guldberg, the incoming executive director of the Phil and Penny Knight Campus for Accelerating Scientific Impact, will introduce the campus community to his research in an upcoming public talk.
Newly identified stem cells in the lung that multiply rapidly after a pulmonary injury may offer an opportunity for innovative future treatments that harness the body’s ability to regenerate.
Fujifilm Global and Takeda Oncology recently announced a collaboration to develop regenerative medicine therapies for the treatment of heart failure using induced pluripotent stem cell (iPSC)-derived cardiomyocytes.
Biodegradable polymeric scaffolds have been used for tissue engineering approaches and can be used to regenerate temporomandibular joint (TMJ) tissues.
The temporomandibular joint (TMJ) is an articulation formed between the temporal bone and the mandibular condyle which is commonly affected. These affections are often so painful during fundamental oral activities that patients have lower quality of life.
A method of making bioink droplets to stick to each other using an enzyme driven crosslinking method has been developed by researchers from Osaka University
Since 2010 global demographics have revealed an ever-increasing elderly population.
Aged patients, who tend to present with partial or total tooth loss, inevitably need more complex and higher quality dental rehabilitation, including dental implant therapy.
Regenerative surgical procedures have long been considered a suitable method for restoring lost periodontal structure and functional attachment.
Jaw Surgery is performed to correct various problems related to the jaw, facial appearance, and other maxillofacial problems.
Bone grafts currently used for the treatment of large bone defect or asymmetry in oral and maxillofacial region include autologous, allogeneic, and artificial bones.
Therapies using mesenchymal stem cell (MSC) seeded scaffolds may be applicable to various fields of regenerative medicine, including craniomaxillofacial surgery.
Although our studies have been successful to a certain degree, advancing to clinical applications, the strategy for practical use of this method has to be changed, because the environment surrounding bone regenerative medicine has evolved dramatically.