Tissue engineering and regenerative medicine approaches harness knowledge of cell populations and the factors that direct cellular function to inform tissue formation.

Microvascular transfer of autologous muscle provides an option for facial reanimation in some cases of facial nerve palsy and for the treatment of certain craniofacial muscle defects.

Emerging bioprinting technologies enable fabrication of constructs for tissue engineering with spatially controlled deposition of cells and biologically active factors to mimic the structural complexity of tissues.

The mechanical strength of metallic biomaterials supports their application in the fabrication of bone fixation plates and in development of scaffolds for bone tissue engineering.

Autografts and allografts are commonly applied in the surgical treatment of craniofacial bone defects, but limitations associated with each have motivated the development of alloplastic graft materials capable of supporting bone tissue regeneration.

Many investigations in recent years have applied injectable hydrogels as carriers for biologically active factors and as cell transplant vehicles for bone tissue regeneration.

The emergence of bioprinting technologies in recent years presents exceptional promise to enable fabrication of patient-specific three-dimensional constructs for tissue engineering and regenerative medicine applications.

Realization of complex three-dimensional structures associated with solid organs through bioprinting approaches presents considerable technical challenges. 

Advances in medical imaging and 3D printing technologies inspire exceptional interest in the fabrication of patient-specific biomaterial-based grafts to support craniofacial bone regeneration, especially in large volume defects.

Regeneration of large volumes of bone with biomaterial-based strategies remains a considerable challenge due in part to the need for vascular support of the regenerating tissue.

A variety of bone graft products have been developed to provide alternatives to autologous bone to fill bony defects. The pathway to clinical translation of bone graft materials typically involves pre-clinical studies in cell culture followed by evaluation of safety and efficacy in pre-clinical animal models.

An Osteo Science Foundation-funded research project.

Volumetric muscle defects, such as those associated with cleft lip, often require multiple surgeries to repair, and the outcomes may be limited in terms of function and cosmesis.

Bone regeneration strategies can include the delivery of multiple therapeutic factors to promote tissue formation.

Many research studies aim to develop biomaterial scaffolds for craniofacial bone tissue regeneration.

Engineering strategies to facilitate regeneration of missing tissues commonly employ biomaterial scaffolds to guide tissue formation. Such approaches often seek to leverage bioresorbable scaffold materials to mitigate potential complications that might be associated with long-term retention of the implanted material.

Tissue engineering scaffolds increasingly seek to mimic complex biomolecular and mechanical gradients reflective of the tissue(s) of interest to guide regeneration, especially at complex tissue interfaces such as the osteochondral interface of the mandibular condyle.

An Osteo Science Foundation-funded research project. 

An Osteo Science Foundation-funded research project

The growth of the field of tissue engineering over the past several decades has been remarkable. While considerable investments continue to be placed in research and development for tissue engineering technologies, translation of the technologies to the clinic to effect patient care remains the ultimate objective.

Autograft bone serves as a standard option for bone regeneration in a variety of contexts in the craniomaxillofacial complex, due in part to the osteoinductivity generally presented by the graft tissue.

Tissue engineering is based on the interaction between stem cells, biomaterials and factors delivered in biological niches.

Tissue-engineered cartilage substitutes, which induce the process of endochondral ossification, represent a regenerative strategy for bone defect healing. 

Adult mouse skeletal stem cells in the jaw revert to a more developmentally flexible state when called upon to regenerate large portions of bone and tissue, according to a study by researchers at the Stanford University School of Medicine.

In patients with compromised health, bone repair and remodeling present a clinical challenge for orthopedic surgeons, with the most common complication being non-union. 

Regenerative surgical procedures have long been considered a suitable method for restoring lost periodontal structure and functional attachment. But how did the concept develop? And what can we expect in the future?

An Osteo Science Foundation-funded research project. 

The goal of a surgical procedure aimed at treating multiple recessions is to achieve complete root coverage that blends with the surrounding soft-tissue and ensures long-term stability with a sulcus depth no greater than 2 mm. The current, most commonly used techniques for treating multi-tooth recessions can be divided into two groups:

Following tooth extraction, the maintenance of the original bone volume is paramount. But what parameters need to be considered?

Bone tissue engineering (BTE) is a developing field in materials science and bioengineering, in which researchers aim to engineer an ideal, bioinspired material to promote assisted bone repair.

Tooth loss is a significant health issue currently affecting millions of people worldwide.

One important aim of the field of tissue engineering (TE) is to replace degenerated tissues with cells and scaffolds that restore tissue function and mediate regeneration. 

Mexico has become a groundbreaker in regenerative medical science. And one institution is touting innovative ways to reduce the prohibitive costs of the therapy. CGTN’s Alasdair Baverstock reports.

No painful graft harvest and very good color and texture match surrounding tissue – these are major advantages when performing a vestibuloplasty with Geistlich Mucograft^®. Now there is long-term data over five years.

The species of simple animal known as Planaria has acted as a model organism in the disciplines of tissue regeneration science for quite a while now.

Oral and maxillofacial surgeons at The University of Texas Health Science Center at Houston (UTHealth) have developed and successfully tested a new surgical technique that could be a critical step toward using bioengineered cartilage to treat temporomandibular joint (TMJ) dysfunction.

An Osteo Science Foundation-funded research project. 

These dental implants rely heavily on the presence of a structured alveolar ridge, as the titanium screw used for fixation requires a specific dimension for insertion.

Facial skin injuries can present exceptional challenges for wound repair considering the complexities of the contours of the face and facial movements.

About five years ago. In the beginning I was skeptical: why should I preserve the ridge, if I could also wait and do implant placement with simultaneous GBR later on?

The study of robotics has been known to yield benefits for humans in a variety of ways; however, a new research study suggests possible benefits but on a different scale.

A major hurdle to using neural stem cells derived from genetically different donors to replace damaged or destroyed tissues, such as in a spinal cord injury, has been the persistent rejection of the introduced material (cells), necessitating the use of complex drugs and techniques to suppress the host’s immune response.

Cardiovascular regeneration focuses on repairing or replacing damaged or senescent cardiac and vascular tissue.

An Osteo Science Foundation-funded research project

An Osteo Science Foundation-funded research project. 

Regenerative medicine is a branch of translational research in tissue engineering and molecular biology which deals with the process of replacing, engineering or regenerating human cells, tissues or organs to restore or establish normal function.

A Purdue University-affiliated startup has devised a way to map arteries in the roof of a person’s mouth to help avoid complications and improve outcomes in oral surgery.

Geistlich invested heavily to develop its latest product, the 3D collagen matrix Geistlich Fibro-Gide^®. Dr. Terance Hart, Director Research, and Dr. Mark Spilker, Chief Scientific Officer, talk about innovation, research pathways and strategic collaborations.

Although connective tissue grafts are the gold standard when it comes to soft tissue augmentation their use is associated with several issues such as anatomical restrictions^1-3 or pain and numbness at the donor site^4,5.

An Osteo Science Foundation-funded research project

Robert E. Guldberg, the incoming executive director of the Phil and Penny Knight Campus for Accelerating Scientific Impact, will introduce the campus community to his research in an upcoming public talk.

Newly identified stem cells in the lung that multiply rapidly after a pulmonary injury may offer an opportunity for innovative future treatments that harness the body’s ability to regenerate.

Fujifilm Global and Takeda Oncology recently announced a collaboration to develop regenerative medicine therapies for the treatment of heart failure using induced pluripotent stem cell (iPSC)-derived cardiomyocytes.

Biodegradable polymeric scaffolds have been used for tissue engineering approaches and can be used to regenerate temporomandibular joint (TMJ) tissues.

The temporomandibular joint (TMJ) is an articulation formed between the temporal bone and the mandibular condyle which is commonly affected. These affections are often so painful during fundamental oral activities that patients have lower quality of life.

The University of Florida has launched a Center for Regenerative Medicine to develop lifesaving therapies “to heal the body from within” using stem cells that repair damaged tissue and organs.

An Osteo Science Foundation-funded research project. 

A method of making bioink droplets to stick to each other using an enzyme driven crosslinking method has been developed by researchers from Osaka University

When newts lose a leg, they regenerate a new one.  Even destroyed cardiac tissue is swiftly replaced by healthy tissue. What is the underlying mechanism?

Since 2010 global demographics have revealed an ever-increasing elderly population.

Aged patients, who tend to present with partial or total tooth loss, inevitably need more complex and higher quality dental rehabilitation, including dental implant therapy.

Regenerative surgical procedures have long been considered a suitable method for restoring lost periodontal structure and functional attachment.

Jaw Surgery is performed to correct various problems related to the jaw, facial appearance, and other maxillofacial problems.

First peri-implantitis occurs, then alveolitis following explantation. How should this case be treated?

Bone is comprised of a mineral and protein scaffold filled with bone cells.

Bisphosphonates and other antiresorptives have been used in various bone diseases for many years.

An Osteo Science Foundation-funded research project. 

Bone grafts currently used for the treatment of large bone defect or asymmetry in oral and maxillofacial region include autologous, allogeneic, and artificial bones.

An Osteo Science Foundation-funded research project.

An Osteo Science Foundation-funded research project. 

An Osteo Science Foundation-funded research project. 

Therapies using mesenchymal stem cell (MSC) seeded scaffolds may be applicable to various fields of regenerative medicine, including craniomaxillofacial surgery. 

An Osteo Science Foundation-funded research project. 

An Osteo Science Foundation-funded research project.

An Osteo Science Foundation-funded research project. 

Although our studies have been successful to a certain degree, advancing to clinical applications, the strategy for practical use of this method has to be changed, because the environment surrounding bone regenerative medicine has evolved dramatically.

An Osteo Science Foundation-funded research project.