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Advances in Regenerative Medicine

 

Cytokines in umbilical code blood-derived cellular product: a mechanistic insight into bone repair

In patients with compromised health, bone repair and remodeling present a clinical challenge for orthopedic surgeons, with the most common complication being non-union. Treatment of bone non-union is critical in preventing progressive deformity, relieving persistent pain and subsequently achieving a total functional recovery.

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Should we extract the tooth and replace it with a dental implant?

Should we extract the tooth and replace it with a dental implant?

Regenerative surgical procedures have long been considered a suitable method for restoring lost periodontal structure and functional attachment. But how did the concept develop? And what can we expect in the future?

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Dealing with extraction sockets

Dealing with extraction sockets

Following tooth extraction, the maintenance of the original bone volume is paramount. But what parameters need to be considered?

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Bioprinting bone substitute materials with cell-laden bioinks

Bioprinting bone substitute materials with cell-laden bioinks

Bone tissue engineering (BTE) is a developing field in materials science and bioengineering, in which researchers aim to engineer an ideal, bioinspired material to promote assisted bone repair.

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Bioengineered tooth replacement opens doors to new therapies

Tooth loss is a significant health issue currently affecting millions of people worldwide.

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Matrix-associated chondrocyte transplantation for reconstruction of articulating surfaces in the temporomandibular joint: a pilot study covering medium- and long-term outcomes of 6 patients

One important aim of the field of tissue engineering (TE) is to replace degenerated tissues with cells and scaffolds that restore tissue function and mediate regeneration. 

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Mexican scientists see stem cells from teeth as future of regenerative medicine

Mexican scientists see stem cells from teeth as future of regenerative medicine

Mexico has become a groundbreaker in regenerative medical science. And one institution is touting innovative ways to reduce the prohibitive costs of the therapy. CGTN’s Alasdair Baverstock reports.

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Using a 3-D collagen matrix for vestibuloplasty

Using a 3-D collagen matrix for vestibuloplasty

No painful graft harvest and very good color and texture match surrounding tissue – these are major advantages when performing a vestibuloplasty with Geistlich Mucograft®. Now there is long-term data over five years.

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How Flatworms Re-Grow Their Own Heads: Scientists Finally Identify The Potential ‘Grail’ Of Regenerative Medicine

How Flatworms Re-Grow Their Own Heads: Scientists Finally Identify The Potential ‘Grail’ Of Regenerative Medicine

The species of simple animal known as Planaria has acted as a model organism in the disciplines of tissue regeneration science for quite a while now.

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UTHealth oral surgeons develop new technique to reconstruct diseased jaw joints

UTHealth oral surgeons develop new technique to reconstruct diseased jaw joints

Oral and maxillofacial surgeons at The University of Texas Health Science Center at Houston (UTHealth) have developed and successfully tested a new surgical technique that could be a critical step toward using bioengineered cartilage to treat temporomandibular joint (TMJ) dysfunction.

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Engineering a New Era: Will Autogenous Tissue Remain the Gold Standard for Head and Neck Reconstruction?

Jazayeri, H. E.; Dorafshar, A. H. “Engineering a New Era: Will Autogenous Tissue Remain the Gold Standard for Head and Neck Reconstruction?”, Journal of Oral and Maxillofacial Surgery, published online: 2018

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HPMC, ZnO, And BG In Alveolar Ridge Augmentation

HPMC, ZnO, And BG In Alveolar Ridge Augmentation

These dental implants rely heavily on the presence of a structured alveolar ridge, as the titanium screw used for fixation requires a specific dimension for insertion.

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A chat with Jung-Chul Park

A chat with Jung-Chul Park

About five years ago. In the beginning I was skeptical: why should I preserve the ridge, if I could also wait and do implant placement with simultaneous GBR later on?

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Robotic Study Could Lead to Quicker Regenerative Medicine Research

Robotic Study Could Lead to Quicker Regenerative Medicine Research

The study of robotics has been known to yield benefits for humans in a variety of ways; however, a new research study suggests possible benefits but on a different scale.

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Scientists successfully graft neural precursor cells into spinal cords of syngeneic pigs with no immunosuppression

Scientists successfully graft neural precursor cells into spinal cords of syngeneic pigs with no immunosuppression

A major hurdle to using neural stem cells derived from genetically different donors to replace damaged or destroyed tissues, such as in a spinal cord injury, has been the persistent rejection of the introduced material (cells), necessitating the use of complex drugs and techniques to suppress the host’s immune response.

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Transflammation: A New Frontier In Regenerative Medicine

Transflammation: A New Frontier In Regenerative Medicine

Cardiovascular regeneration focuses on repairing or replacing damaged or senescent cardiac and vascular tissue.

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3D Bioprinted Scaffold-free Nerve Constructs with Human Gingiva-derived Mesenchymal Stem Cells as Bioink Promote Rat Facial Nerve Regeneration.

Despite the promising neuro-regenerative capacities of stem cells, there is currently no licensed stem cell-based product in the repair and regeneration of peripheral nerve injuries. Here, we explored the potential use of human gingiva-derived mesenchymal stem cells (GMSCs) as the only cellular component in 3D bio-printed scaffold-free neural constructs that were transplantable to bridge facial nerve defects in rats.

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Regenerative Medicine Market Is Expected To Grow 23.54% CAGR till 2025

Regenerative Medicine Market Is Expected To Grow 23.54% CAGR till 2025

Regenerative medicine is a branch of translational research in tissue engineering and molecular biology which deals with the process of replacing, engineering or regenerating human cells, tissues or organs to restore or establish normal function.

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Mapping arteries could help avoid complications and improve outcomes in oral surgeries

Mapping arteries could help avoid complications and improve outcomes in oral surgeries

Purdue University-affiliated startup has devised a way to map arteries in the roof of a person’s mouth to help avoid complications and improve outcomes in oral surgery.

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“It’s not only science. There is a lot of art involved.”

“It’s not only science. There is a lot of art involved.”

Geistlich invested heavily to develop its latest product, the 3D collagen matrix Geistlich Fibro-Gide®. Dr. Terance Hart, Director Research, and Dr. Mark Spilker, Chief Scientific Officer, talk about innovation, research pathways and strategic collaborations.

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A breakthrough in soft-tissue regeneration

A breakthrough in soft-tissue regeneration

Although connective tissue grafts are the gold standard when it comes to soft tissue augmentation their use is associated with several issues such as anatomical restrictions1-3 or pain and numbness at the donor site4,5.

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New Knight Campus director to discuss regenerative medicine

New Knight Campus director to discuss regenerative medicine

Robert E. Guldberg, the incoming executive director of the Phil and Penny Knight Campus for Accelerating Scientific Impact, will introduce the campus community to his research in an upcoming public talk.

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New Stem Cell Found in Lung, May Offer Target for Regenerative Medicine

New Stem Cell Found in Lung, May Offer Target for Regenerative Medicine

Newly identified stem cells in the lung that multiply rapidly after a pulmonary injury may offer an opportunity for innovative future treatments that harness the body’s ability to regenerate.

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Fujifilm, Takeda Partner on Regenerative Medicine Therapies

Fujifilm, Takeda Partner on Regenerative Medicine Therapies

Fujifilm Global and Takeda Oncology recently announced a collaboration to develop regenerative medicine therapies for the treatment of heart failure using induced pluripotent stem cell (iPSC)-derived cardiomyocytes.

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Regenerative Potential of Various Soft Polymeric Scaffolds in the Temporomandibular Joint Condyle

Regenerative Potential of Various Soft Polymeric Scaffolds in the Temporomandibular Joint Condyle

Biodegradable polymeric scaffolds have been used for tissue engineering approaches and can be used to regenerate temporomandibular joint (TMJ) tissues.

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UF Launches New Center for Regenerative Medicine

UF Launches New Center for Regenerative Medicine

The University of Florida has launched a Center for Regenerative Medicine to develop lifesaving therapies “to heal the body from within” using stem cells that repair damaged tissue and organs.

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Neural Crest Stem-Like Cells Non-genetically Induced from Human Gingiva-Derived Mesenchymal Stem Cells Promote Facial Nerve Regeneration in Rats. Mol Neurobiol

Non-genetic induction of somatic cells into neural crest stem-like cells (NCSCs) is promising for potential cell-based therapies for post-traumatic peripheral nerve regeneration.

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Printing Human Body Parts: Bio-Ink Drops Showing Promise for Regenerative Medicine

Printing Human Body Parts: Bio-Ink Drops Showing Promise for Regenerative Medicine

A method of making bioink droplets to stick to each other using an enzyme driven crosslinking method has been developed by researchers from Osaka University

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Heart renewal in newts

Heart renewal in newts

When newts lose a leg, they regenerate a new one.  Even destroyed cardiac tissue is swiftly replaced by healthy tissue. What is the underlying mechanism?

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Augmentation Procedures for Geriatric Patients

Augmentation Procedures for Geriatric Patients

Since 2010 global demographics have revealed an ever-increasing elderly population.

Aged patients, who tend to present with partial or total tooth loss, inevitably need more complex and higher quality dental rehabilitation, including dental implant therapy.

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Should we extract the tooter and replace it with a dental implant?

Regenerative surgical procedures have long been considered a suitable method for restoring lost periodontal structure and functional attachment.

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Engineering a New Era: Will Autogenous Tissue Remain the Gold Standard for Head and Neck Reconstruction?

The evolution of head and neck reconstruction dates to approximately 1000 BC, when Sushruta, the father of Indian surgery, introduced the
the theory for arguably the first regional pedicled flap in rhinoplasty. Ancient Egyptian, Greek, Persian, and Indian civilizations expanded on this medical marvel by contributing to discoveries in human anatomy, whereas Roman physicians described possibilities for local tissue rearrangements for nearly all segments of the face.

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Jaw Surgery Market | Rising Demand for Jaw Surgery Drives Growth of The Global Market

Jaw Surgery Market | Rising Demand for Jaw Surgery Drives Growth of The Global Market

Jaw Surgery is performed to correct various problems related to the jaw, facial appearance, and other maxillofacial problems.

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Loss of a transplant due to alveolitis

Loss of a transplant due to alveolitis

First peri-implantitis occurs, then alveolitis following explantation. How should this case be treated?

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Mechanisms of Age-Related Bone Loss

Mechanisms of Age-Related Bone Loss

Bone is comprised of a mineral and protein scaffold filled with bone cells.

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Bisphosphonates

Bisphosphonates

Bisphosphonates and other antiresorptives have been used in various bone diseases for many years.

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Small molecule-mediated tribbles homolog 3 promotes bone formation induced by bone morphogenetic protein-2.

Although bone morphogenetic protein-2 (BMP2) has demonstrated extraordinary potential in bone formation, its clinical applications require supraphysiological milligram-level doses that increase postoperative inflammation and inappropriate adipogenesis, resulting in well-documented life threatening cervical swelling and cyst-like bone formation.

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Rapid Bioorthogonal Chemistry Turn–on through Enzymatic or Long Wavelength Photocatalytic Activation of Tetrazine Ligation

Rapid bioorthogonal reactivity can be induced by controllable, catalytic stimuli using air as the oxidant.

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A Fast-Degrading Thiol-Acrylate based Hydrogel for Cranial Regeneration, Journal of Biomaterials.

Successful regeneration of the cranium in patients suffering from cranial bone defects is an integral step to restore craniofacial function.

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Ovine Model For Generation of Tissue-Engineered Vascularized Bone of Large Volume and Custom Geometry

Dilated cardiomyopathy (DCM) is a multivariate disease with poorly understood mechanisms, but recently 30+ different mutations have been suggested to contribute to disease pathology.

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Reconstruction of Large Mandibular Defects Using Autologous Tissues Generated From In Vivo Bioreactors

Reconstruction of large mandibular defects is clinically challenging due to the need for donor tissue of appropriate shape and volume to facilitate high fidelity repair.

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Regulation of Epithelial–to–Mesenchymal Transition Using Biomimetic Fibrous Scaffolds

Epithelial-to-mesenchymal transition (EMT) is a well-studied biological process that takes place during embryogenesis, carcinogenesis and tissue fibrosis.

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Roles of the Fibrous Superficial Zone in the Mechanical Behavior of TMJ Condylar Cartilage

In temporomandibular joints (TMJs), the cartilage on the condylar head displays a unique ultrastructure with a dense layer of type I collagen in the superficial zone, different from hyaline cartilage in other joints.

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CONTACT

Osteo Science Foundation
1650 Market Street, Suite 3600
Philadelphia, PA 19103
215-977-2877
855-891-2877 Toll Free
info@osteoscience.org

Osteo Science Foundation is an independent, privately funded 501 (c) (3) non-profit organization.

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