Search Articles Related to Advances in Regernative Medicine

Multivascular Networks and Functional Intravascular Topologies within Biocompatible Hydrogels

Multivascular Networks and Functional Intravascular Topologies within Biocompatible Hydrogels

Realization of complex three-dimensional structures associated with solid organs through bioprinting approaches presents considerable technical challenges. 

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Dipyridamole Augments Three-Dimensionally Printed Bioactive Ceramic Scaffolds to Regenerate Craniofacial Bone

Dipyridamole Augments Three-Dimensionally Printed Bioactive Ceramic Scaffolds to Regenerate Craniofacial Bone

Advances in medical imaging and 3D printing technologies inspire exceptional interest in the fabrication of patient-specific biomaterial-based grafts to support craniofacial bone regeneration, especially in large volume defects.

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Perfusion Bioreactor Culture of Bone Marrow Stromal Cells Enhances Cranial Defect Regeneration

Perfusion Bioreactor Culture of Bone Marrow Stromal Cells Enhances Cranial Defect Regeneration

Regeneration of large volumes of bone with biomaterial-based strategies remains a considerable challenge due in part to the need for vascular support of the regenerating tissue.

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Culture of hybrid spheroids composed of calcium phosphate materials and mesenchymal stem cells on an oxygen-permeable culture device to predict in vivo bone forming capability

Culture of hybrid spheroids composed of calcium phosphate materials and mesenchymal stem cells on an oxygen-permeable culture device to predict in vivo bone forming capability

A variety of bone graft products have been developed to provide alternatives to autologous bone to fill bony defects. The pathway to clinical translation of bone graft materials typically involves pre-clinical studies in cell culture followed by evaluation of safety and efficacy in pre-clinical animal models.

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Osteogenic magnesium incorporated into PLGA/TCP porous scaffold by 3D printing for repairing challenging bone defect

Osteogenic magnesium incorporated into PLGA/TCP porous scaffold by 3D printing for repairing challenging bone defect

Scaffold-based approaches for bone regeneration often incorporate biologically active factors to facilitate desired outcomes, including bone formation and vascularization. Literature over the years suggests that magnesium may present osteogenic and angiogenic potential in certain contexts, which might be leveraged in regenerative medicine approaches to bone tissue repair.

 

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Biomaterials-aided mandibular reconstruction using in vivo bioreactors

Biomaterials-aided mandibular reconstruction using in vivo bioreactors

An Osteo Science Foundation-funded research project.

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In Silico and In Vivo Studies Detect Functional Repair Mechanisms in a Volumetric Muscle Loss Injury

In Silico and In Vivo Studies Detect Functional Repair Mechanisms in a Volumetric Muscle Loss Injury

Volumetric muscle defects, such as those associated with cleft lip, often require multiple surgeries to repair, and the outcomes may be limited in terms of function and cosmesis.

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Fabrication of a nanoparticle-containing 3D porous bone scaffold with proangiogenic and antibacterial properties

Fabrication of a nanoparticle-containing 3D porous bone scaffold with proangiogenic and antibacterial properties

Bone regeneration strategies can include the delivery of multiple therapeutic factors to promote tissue formation.

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Mineralized nanofiber segments coupled with calcium-binding BMP-2 peptides for alveolar bone regeneration

Mineralized nanofiber segments coupled with calcium-binding BMP-2 peptides for alveolar bone regeneration

Biomaterial-based approaches to facilitate alveolar bone regeneration remain a focus for investigation owing to the importance of bone of sufficient quantity and quality to support surgically placed dental implants.

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3D-printed, externally-implanted, bioresorbable airway splints for severe tracheobronchomalacia

3D-printed, externally-implanted, bioresorbable airway splints for severe tracheobronchomalacia

Engineering strategies to facilitate regeneration of missing tissues commonly employ biomaterial scaffolds to guide tissue formation. Such approaches often seek to leverage bioresorbable scaffold materials to mitigate potential complications that might be associated with long-term retention of the implanted material.

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A simple layer-stacking technique to generate biomolecular and mechanical gradients in photocrosslinkable hydrogels

A simple layer-stacking technique to generate biomolecular and mechanical gradients in photocrosslinkable hydrogels

Tissue engineering scaffolds increasingly seek to mimic complex biomolecular and mechanical gradients reflective of the tissue(s) of interest to guide regeneration, especially at complex tissue interfaces such as the osteochondral interface of the mandibular condyle.

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Development and Characterization of a Rabbit Model of Compromised Maxillofacial Wound Healing.

Development and Characterization of a Rabbit Model of Compromised Maxillofacial Wound Healing.

An Osteo Science Foundation-funded research project

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Scalable MSC-derived Bone Tissue Modules

Scalable MSC-derived Bone Tissue Modules

Emerging modular tissue engineering approaches seek to enable the generation of large-scale tissues from the assembly or fusion of small-scale cellular constructs generated in culture. While modular tissue engineering approaches present advantages with respect to maintaining cell viability in culture prior to assembly of the building blocks, generation of modular constructs with suitable mechanical properties for load-bearing bone regeneration presents a challenge.

 

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An Overview of the Tissue Engineering Market in the United States from 2011 to 2018

An Overview of the Tissue Engineering Market in the United States from 2011 to 2018

The growth of the field of tissue engineering over the past several decades has been remarkable. While considerable investments continue to be placed in research and development for tissue engineering technologies, translation of the technologies to the clinic to effect patient care remains the ultimate objective.

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Poly(Thioketal Urethane) Autograft Extenders in an Intertransverse Process Model of Bone Formation

Poly(Thioketal Urethane) Autograft Extenders in an Intertransverse Process Model of Bone Formation

Autograft bone serves as a standard option for bone regeneration in a variety of contexts in the craniomaxillofacial complex, due in part to the osteoinductivity generally presented by the graft tissue.

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Commitment of Oral-Derived Stem Cells in Dental and Maxillofacial Applications

Commitment of Oral-Derived Stem Cells in Dental and Maxillofacial Applications

Tissue engineering is based on the interaction between stem cells, biomaterials and factors delivered in biological niches.

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Regulatory Interfaces Surrounding The Growing Field of Additive Manufacturing of Medical Devices and Biologic Products

Regulatory Interfaces Surrounding The Growing Field of Additive Manufacturing of Medical Devices and Biologic Products

The potential impacts of 3D printing in medicine appear to be remarkable, but regulatory pathways associated with the clinical translation of devices and products produced through 3D printing struggle to maintain pace with the rapidly evolving technologies.

 

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The impact of immune response on endochondral bone regeneration

The impact of immune response on endochondral bone regeneration

Tissue-engineered cartilage substitutes, which induce the process of endochondral ossification, represent a regenerative strategy for bone defect healing. 

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Skeletal stem cells regress when tasked with extensive regeneration

Skeletal stem cells regress when tasked with extensive regeneration

Adult mouse skeletal stem cells in the jaw revert to a more developmentally flexible state when called upon to regenerate large portions of bone and tissue, according to a study by researchers at the Stanford University School of Medicine.

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Cytokines in umbilical code blood-derived cellular product: a mechanistic insight into bone repair

Cytokines in umbilical code blood-derived cellular product: a mechanistic insight into bone repair

In patients with compromised health, bone repair and remodeling present a clinical challenge for orthopedic surgeons, with the most common complication being non-union. 

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Should we extract the tooth and replace it with a dental implant?

Should we extract the tooth and replace it with a dental implant?

Regenerative surgical procedures have long been considered a suitable method for restoring lost periodontal structure and functional attachment. But how did the concept develop? And what can we expect in the future?

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Channels in a porous scaffold: a new player for vascularization

Channels in a porous scaffold: a new player for vascularization

An Osteo Science Foundation-funded research project. 

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Recession Coverage: A less invasive tunneling technique for multiple recession defects

Recession Coverage: A less invasive tunneling technique for multiple recession defects

The goal of a surgical procedure aimed at treating multiple recessions is to achieve complete root coverage that blends with the surrounding soft-tissue and ensures long-term stability with a sulcus depth no greater than 2 mm. The current, most commonly used techniques for treating multi-tooth recessions can be divided into two groups:

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Dealing with extraction sockets

Dealing with extraction sockets

Following tooth extraction, the maintenance of the original bone volume is paramount. But what parameters need to be considered?

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Bioprinting bone substitute materials with cell-laden bioinks

Bioprinting bone substitute materials with cell-laden bioinks

Bone tissue engineering (BTE) is a developing field in materials science and bioengineering, in which researchers aim to engineer an ideal, bioinspired material to promote assisted bone repair.

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Bioengineered tooth replacement opens doors to new therapies

Bioengineered tooth replacement opens doors to new therapies

Tooth loss is a significant health issue currently affecting millions of people worldwide.

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Matrix-associated chondrocyte transplantation for reconstruction of articulating surfaces in the temporomandibular joint: a pilot study covering medium- and long-term outcomes of 6 patients

Matrix-associated chondrocyte transplantation for reconstruction of articulating surfaces in the temporomandibular joint: a pilot study covering medium- and long-term outcomes of 6 patients

One important aim of the field of tissue engineering (TE) is to replace degenerated tissues with cells and scaffolds that restore tissue function and mediate regeneration. 

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Mexican scientists see stem cells from teeth as future of regenerative medicine

Mexican scientists see stem cells from teeth as future of regenerative medicine

Mexico has become a groundbreaker in regenerative medical science. And one institution is touting innovative ways to reduce the prohibitive costs of the therapy. CGTN’s Alasdair Baverstock reports.

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Using a 3-D collagen matrix for vestibuloplasty

Using a 3-D collagen matrix for vestibuloplasty

No painful graft harvest and very good color and texture match surrounding tissue – these are major advantages when performing a vestibuloplasty with Geistlich Mucograft®. Now there is long-term data over five years.

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How Flatworms Re-Grow Their Own Heads: Scientists Finally Identify The Potential ‘Grail’ Of Regenerative Medicine

How Flatworms Re-Grow Their Own Heads: Scientists Finally Identify The Potential ‘Grail’ Of Regenerative Medicine

The species of simple animal known as Planaria has acted as a model organism in the disciplines of tissue regeneration science for quite a while now.

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UTHealth oral surgeons develop new technique to reconstruct diseased jaw joints

UTHealth oral surgeons develop new technique to reconstruct diseased jaw joints

Oral and maxillofacial surgeons at The University of Texas Health Science Center at Houston (UTHealth) have developed and successfully tested a new surgical technique that could be a critical step toward using bioengineered cartilage to treat temporomandibular joint (TMJ) dysfunction.

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Engineering a New Era: Will Autogenous Tissue Remain the Gold Standard for Head and Neck Reconstruction?

Engineering a New Era: Will Autogenous Tissue Remain the Gold Standard for Head and Neck Reconstruction?

An Osteo Science Foundation-funded research project. 

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HPMC, ZnO, And BG In Alveolar Ridge Augmentation

HPMC, ZnO, And BG In Alveolar Ridge Augmentation

These dental implants rely heavily on the presence of a structured alveolar ridge, as the titanium screw used for fixation requires a specific dimension for insertion.

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3D Bioprinted Biomask For Facial Skin Reconstruction

3D Bioprinted Biomask For Facial Skin Reconstruction

Facial skin injuries can present exceptional challenges for wound repair considering the complexities of the contours of the face and facial movements.

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A chat with Jung-Chul Park

A chat with Jung-Chul Park

About five years ago. In the beginning I was skeptical: why should I preserve the ridge, if I could also wait and do implant placement with simultaneous GBR later on?

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Robotic Study Could Lead to Quicker Regenerative Medicine Research

Robotic Study Could Lead to Quicker Regenerative Medicine Research

The study of robotics has been known to yield benefits for humans in a variety of ways; however, a new research study suggests possible benefits but on a different scale.

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Scientists successfully graft neural precursor cells into spinal cords of syngeneic pigs with no immunosuppression

Scientists successfully graft neural precursor cells into spinal cords of syngeneic pigs with no immunosuppression

A major hurdle to using neural stem cells derived from genetically different donors to replace damaged or destroyed tissues, such as in a spinal cord injury, has been the persistent rejection of the introduced material (cells), necessitating the use of complex drugs and techniques to suppress the host’s immune response.

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Transflammation: A New Frontier In Regenerative Medicine

Transflammation: A New Frontier In Regenerative Medicine

Cardiovascular regeneration focuses on repairing or replacing damaged or senescent cardiac and vascular tissue.

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Regulatory pathways and barriers to implementation of tissue engineering and regenerative medicine.

Regulatory pathways and barriers to implementation of tissue engineering and regenerative medicine.

An Osteo Science Foundation-funded research project

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Regenerative Medicine Market Is Expected To Grow 23.54% CAGR till 2025

Regenerative Medicine Market Is Expected To Grow 23.54% CAGR till 2025

Regenerative medicine is a branch of translational research in tissue engineering and molecular biology which deals with the process of replacing, engineering or regenerating human cells, tissues or organs to restore or establish normal function.

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Mapping arteries could help avoid complications and improve outcomes in oral surgeries

Mapping arteries could help avoid complications and improve outcomes in oral surgeries

Purdue University-affiliated startup has devised a way to map arteries in the roof of a person’s mouth to help avoid complications and improve outcomes in oral surgery.

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“It’s not only science. There is a lot of art involved.”

“It’s not only science. There is a lot of art involved.”

Geistlich invested heavily to develop its latest product, the 3D collagen matrix Geistlich Fibro-Gide®. Dr. Terance Hart, Director Research, and Dr. Mark Spilker, Chief Scientific Officer, talk about innovation, research pathways and strategic collaborations.

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A breakthrough in soft-tissue regeneration

A breakthrough in soft-tissue regeneration

Although connective tissue grafts are the gold standard when it comes to soft tissue augmentation their use is associated with several issues such as anatomical restrictions1-3 or pain and numbness at the donor site4,5.

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Regulating Non-Viable Tissue

Regulating Non-Viable Tissue

An Osteo Science Foundation-funded research project

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New Knight Campus director to discuss regenerative medicine

New Knight Campus director to discuss regenerative medicine

Robert E. Guldberg, the incoming executive director of the Phil and Penny Knight Campus for Accelerating Scientific Impact, will introduce the campus community to his research in an upcoming public talk.

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New Stem Cell Found in Lung, May Offer Target for Regenerative Medicine

New Stem Cell Found in Lung, May Offer Target for Regenerative Medicine

Newly identified stem cells in the lung that multiply rapidly after a pulmonary injury may offer an opportunity for innovative future treatments that harness the body’s ability to regenerate.

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Fujifilm, Takeda Partner on Regenerative Medicine Therapies

Fujifilm, Takeda Partner on Regenerative Medicine Therapies

Fujifilm Global and Takeda Oncology recently announced a collaboration to develop regenerative medicine therapies for the treatment of heart failure using induced pluripotent stem cell (iPSC)-derived cardiomyocytes.

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Regenerative Potential of Various Soft Polymeric Scaffolds in the Temporomandibular Joint Condyle

Regenerative Potential of Various Soft Polymeric Scaffolds in the Temporomandibular Joint Condyle

Biodegradable polymeric scaffolds have been used for tissue engineering approaches and can be used to regenerate temporomandibular joint (TMJ) tissues.

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Temporomandibular Joint Regenerative Medicine

Temporomandibular Joint Regenerative Medicine

The temporomandibular joint (TMJ) is an articulation formed between the temporal bone and the mandibular condyle which is commonly affected. These affections are often so painful during fundamental oral activities that patients have lower quality of life.

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UF Launches New Center for Regenerative Medicine

UF Launches New Center for Regenerative Medicine

The University of Florida has launched a Center for Regenerative Medicine to develop lifesaving therapies “to heal the body from within” using stem cells that repair damaged tissue and organs.

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Printing Human Body Parts: Bio-Ink Drops Showing Promise for Regenerative Medicine

Printing Human Body Parts: Bio-Ink Drops Showing Promise for Regenerative Medicine

A method of making bioink droplets to stick to each other using an enzyme driven crosslinking method has been developed by researchers from Osaka University

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Heart renewal in newts

Heart renewal in newts

When newts lose a leg, they regenerate a new one.  Even destroyed cardiac tissue is swiftly replaced by healthy tissue. What is the underlying mechanism?

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Augmentation Procedures for Geriatric Patients

Augmentation Procedures for Geriatric Patients

Since 2010 global demographics have revealed an ever-increasing elderly population.

Aged patients, who tend to present with partial or total tooth loss, inevitably need more complex and higher quality dental rehabilitation, including dental implant therapy.

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Should we extract the tooter and replace it with a dental implant?

Should we extract the tooter and replace it with a dental implant?

Regenerative surgical procedures have long been considered a suitable method for restoring lost periodontal structure and functional attachment.

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Jaw Surgery Market | Rising Demand for Jaw Surgery Drives Growth of The Global Market

Jaw Surgery Market | Rising Demand for Jaw Surgery Drives Growth of The Global Market

Jaw Surgery is performed to correct various problems related to the jaw, facial appearance, and other maxillofacial problems.

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Loss of a transplant due to alveolitis

Loss of a transplant due to alveolitis

First peri-implantitis occurs, then alveolitis following explantation. How should this case be treated?

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Mechanisms of Age-Related Bone Loss

Mechanisms of Age-Related Bone Loss

Bone is comprised of a mineral and protein scaffold filled with bone cells.

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Bisphosphonates

Bisphosphonates

Bisphosphonates and other antiresorptives have been used in various bone diseases for many years.

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Small molecule-mediated tribbles homolog 3 promotes bone formation induced by bone morphogenetic protein-2.

Small molecule-mediated tribbles homolog 3 promotes bone formation induced by bone morphogenetic protein-2.

An Osteo Science Foundation-funded research project. 

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Bone Regenerative Medicine in Oral and Maxillofacial Region Using a Three-Dimensional Printer

Bone Regenerative Medicine in Oral and Maxillofacial Region Using a Three-Dimensional Printer

Bone grafts currently used for the treatment of large bone defect or asymmetry in oral and maxillofacial region include autologous, allogeneic, and artificial bones.

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A Fast-Degrading Thiol-Acrylate Based Hydrogel For Cranial Regeneration

A Fast-Degrading Thiol-Acrylate Based Hydrogel For Cranial Regeneration

An Osteo Science Foundation-funded research project. 

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Accelerated craniofacial bone regeneration through dense collagen gel scaffolds seeded with dental pulp stem cells

Accelerated craniofacial bone regeneration through dense collagen gel scaffolds seeded with dental pulp stem cells

Therapies using mesenchymal stem cell (MSC) seeded scaffolds may be applicable to various fields of regenerative medicine, including craniomaxillofacial surgery. 

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Ovine Model For Generation of Tissue-Engineered Vascularized Bone of Large Volume and Custom Geometry

Ovine Model For Generation of Tissue-Engineered Vascularized Bone of Large Volume and Custom Geometry

An Osteo Science Foundation-funded research project. 

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Reconstruction of Large Mandibular Defects Using Autologous Tissues Generated From In Vivo Bioreactors

Reconstruction of Large Mandibular Defects Using Autologous Tissues Generated From In Vivo Bioreactors

An Osteo Science Foundation-funded research project.

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Regulation of Epithelial–to–Mesenchymal Transition Using Biomimetic Fibrous Scaffolds

Regulation of Epithelial–to–Mesenchymal Transition Using Biomimetic Fibrous Scaffolds

An Osteo Science Foundation-funded research project. 

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Clinical review of bone regenerative medicine and maxillomandibular reconstruction

Clinical review of bone regenerative medicine and maxillomandibular reconstruction

Although our studies have been successful to a certain degree, advancing to clinical applications, the strategy for practical use of this method has to be changed, because the environment surrounding bone regenerative medicine has evolved dramatically.

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Roles of the Fibrous Superficial Zone in the Mechanical Behavior of TMJ Condylar Cartilage

Roles of the Fibrous Superficial Zone in the Mechanical Behavior of TMJ Condylar Cartilage

An Osteo Science Foundation-funded research project.

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