Defects in the maxillofacial skeleton often present with a compromised wound bed and associated challenges to repair. However, pre-clinical investigation of tissue engineering and regenerative medicine strategies seeking to facilitate repair of such defects commonly involves a healthy animal model presenting an ideal wound bed.
Accordingly, strategies with positive outcomes in healthy pre-clinical animal models may fail to meet the needs of the complex wound bed upon transition to the clinic. A recent article by Piotrowski et al. describes a rabbit model of compromised maxillofacial wound healing. The study demonstrates that fractionated radiation to the mandible significantly compromised tissue healing in a critically sized bony defect in the mandible when compared to a control group without irradiation. The compromised wound healing model outlined in the report may present a clinically-relevant environment for the pre-clinical evaluation of technologies for maxillofacial bone regeneration.
Development and Characterization of a Rabbit Model of Compromised Maxillofacial Wound Healing.
Piotrowski S, Wilson L, Dharmaraj N, Hamze A, Clark A, Tailor R, Hill L, Lai S, Kasper FK, Young S. Tissue Eng Part C Methods. 2019 Feb 12. doi: 10.1089/ten.TEC.2018.0361. [Epub ahead of print]