Dose Effects of Slow-Released Bone Morphogenetic Protein-2 Functionalized β-Tricalcium Phosphate in Repairing Critical-Sized Bone Defects

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Dose Effects of Slow-Released Bone Morphogenetic Protein-2 Functionalized β-Tricalcium Phosphate in Repairing Critical-Sized Bone Defects

Augmentation of bone graft materials with osteoinductive recombinant human bone morphogenetic protein-2 (rhBMP-2) has realized clinical success for craniofacial bone regeneration in some cases. However, costs associated with commercial production of rhBMP-2 in mammalian cell culture and concerns regarding dosing at the site of application limit application of the approach. A recent article by Wei et al. investigated the dose effects of Escherichia coli-derived rhBMP-2 (ErhBMP-2) on bone regeneration in a critical-sized calvarial defect model in a rat. The authors treated the defects with b-tricalcium phosphate granules coated with biomimetic crystalline calcium phosphate with or without inclusion of ErhBMP-2. Autologous bone grafts and empty defects served as controls. Incorporation of the ErhBMP-2 in the calcium phosphate coating enabled a slow cell-mediated release of the osteoinductive factor. The authors reported comparable efficacy of the ErhBMP-2-funcationalized scaffolds with autologous bone in terms of bone formation at 8 weeks. While the dose of ErhBMP-2 did not have a significant effect on bone formation, higher doses resulted in increased bone maturation. Overall, the study provides stimulating insight regarding potential alternative sources of rhBMP-2 for the commercial development of bone regeneration therapies.

Citation Information:

Wei L, Yu D, Wang M, Deng L, Wu G, Liu Y. Tissue Eng Part A. 2019. doi: 10.1089/ten.TEA.2019.0161.

PMID: 31436137

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