Bone regeneration strategies can include the delivery of multiple therapeutic factors to promote tissue formation.
In some cases, local delivery of tissue inductive factors in combination with antibiotics may be warranted to address potential wound contamination while facilitating tissue repair. A recent article by Paris et al. reports fabrication of a 3D porous scaffold comprising agarose and nanocrystalline apatite as structural elements and mesoporous silica nanoparticles as a vehicle for controlled local release of an angiogenic protein (vascular endothelial growth factor) and an antibiotic (cephalexin). The authors report that the surfaces of the scaffolds supported adhesion of preosteoblasts and that release of cephalexin from the scaffold could inhibit growth of Staphylococcus aureus in culture. They also report an angiogenic effect of vascular endothelial growth factor release from the scaffolds in a chick embryo chorioallantoic membrane model. Overall, the article suggests the potential feasibility of osteoconductive 3D scaffolds releasing angiogenic factors in support of bone regeneration and antibiotics to mitigate infection.Citation Information:Fabrication of a nanoparticle-containing 3D porous bone scaffold with proangiogenic and antibacterial properties.
Paris JL, Lafuente-Gómez N, Cabañas MV, Román J, Peña J, Vallet-Regí M. Acta Biomater. 2019;86:441-449.