Regenerative Medicine Article Image

Fabrication of a nanoparticle-containing 3D porous bone scaffold with proangiogenic and antibacterial properties

Bone regeneration strategies can include the delivery of multiple therapeutic factors to promote tissue formation.

In some cases, local delivery of tissue inductive factors in combination with antibiotics may be warranted to address potential wound contamination while facilitating tissue repair. A recent article by Paris et al. reports fabrication of a 3D porous scaffold comprising agarose and nanocrystalline apatite as structural elements and mesoporous silica nanoparticles as a vehicle for controlled local release of an angiogenic protein (vascular endothelial growth factor) and an antibiotic (cephalexin). The authors report that the surfaces of the scaffolds supported adhesion of preosteoblasts and that release of cephalexin from the scaffold could inhibit growth of Staphylococcus aureus in culture. They also report an angiogenic effect of vascular endothelial growth factor release from the scaffolds in a chick embryo chorioallantoic membrane model. Overall, the article suggests the potential feasibility of osteoconductive 3D scaffolds releasing angiogenic factors in support of bone regeneration and antibiotics to mitigate infection.Citation Information:Fabrication of a nanoparticle-containing 3D porous bone scaffold with proangiogenic and antibacterial properties.

Paris JL, Lafuente-Gómez N, Cabañas MV, Román J, Peña J, Vallet-Regí M. Acta Biomater. 2019;86:441-449.

PMID: 30654210

Continue Reading


Osteo Science Foundation
1650 Market Street, Suite 3600
Philadelphia, PA 19103
855-891-2877 Toll Free

Osteo Science Foundation is an independent, privately funded 501 (c) (3) non-profit organization.


By submitting this form, you are consenting to receive marketing emails from: Osteo Science Foundation, 1650 Market Street, Suite 2600, Philadelphia, PA, 19103, US. You can revoke your consent to receive emails at any time by using the SafeUnsubscribe® link, found at the bottom of every email. Emails are serviced by Constant Contact.

%d bloggers like this: