ARM Article - Kelly

Fatigue behavior of As-built selective laser melted titanium scaffolds with sheet-based gyroid microarchitecture for bone tissue engineering

The mechanical strength of metallic biomaterials supports their application in the fabrication of bone fixation plates and in development of scaffolds for bone tissue engineering.

The introduction of porosity into metallic scaffold structures provides void volume to enable cell migration and tissue formation, while promoting mechanotransduction with surrounding bone tissue. However, some topologies present stress risers that deleteriously affect the mechanical properties of the porous scaffolds. Advances in recent years in additive manufacturing technologies, such as 3D printing, enable realization of mathematical function-defined porous architectures with continuous curvature that may decrease stress risers. A recent article by Kelly et al. applied selective laser melting (SLM) technology to fabricate porous titanium structures with mathematical function-derived triply periodic minimal surfaces (TMPS). The authors investigated the effects of microarchitecture, such as wall thickness, and SLM laser parameters on the compressive and tensile mechanical properties, including fatigue behavior. The authors fabricated titanium scaffolds with porosity ranges comparable to trabecular bone and presenting mechanical properties within the range of trabecular and cortical bone. The authors demonstrated that the mechanical properties could be modulated through adjustment of the microarchitecture and the laser parameters. Overall, the article suggests the potential of additive manufacturing to enable fabrication of metallic scaffolds with porosities and mechanical properties tuned for bone tissue engineering applications. The implications of the work may extend more broadly to inform metallic implant design in craniofacial and orthopedic bone fixation applications, where mechanotransduction and osseointegration may be desired.

 

Citation Information:

Fatigue behavior of As-built selective laser melted titanium scaffolds with sheet-based gyroid microarchitecture for bone tissue engineering.

Kelly CN, Francovich J, Julmi S, Safranski D, Guldberg RE, Maier HJ, Gall K. Acta Biomater. 2019;94:610-626.

PMID: 31125727

Continue Reading

 

CONTACT

Osteo Science Foundation
1650 Market Street, Suite 3600
Philadelphia, PA 19103
215-977-2877
855-891-2877 Toll Free
info@osteoscience.org

Osteo Science Foundation is an independent, privately funded 501 (c) (3) non-profit organization.

SIGN UP FOR NEWS

By submitting this form, you are consenting to receive marketing emails from: Osteo Science Foundation, 1650 Market Street, Suite 2600, Philadelphia, PA, 19103, US. You can revoke your consent to receive emails at any time by using the SafeUnsubscribe® link, found at the bottom of every email. Emails are serviced by Constant Contact.