Clinical review of bone regenerative medicine and maxillomandibular reconstruction

Although our studies have been successful to a certain degree, advancing to clinical applications, the strategy for practical use of this method has to be changed, because the environment surrounding bone regenerative medicine has evolved dramatically.

Therefore, we have changed our focus from cells to cell-conditioned media, and we found that the latter contains growth factors and matrices released from the cells and promotes regeneration of tissues by recruiting endogenous stem cells and precursor cells, and thereby started clinical research based on these findings.

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