Volumetric muscle defects, such as those associated with cleft lip, often require multiple surgeries to repair, and the outcomes may be limited in terms of function and cosmesis. While tissue engineering strategies are being explored to facilitate repair of volumetric muscle defects in pre-clinical models, the models typically involve muscles in the extremities that do not reflect the delicate and complex architecture of craniofacial muscles.
In Silico and In Vivo Studies Detect Functional Repair Mechanisms in a Volumetric Muscle Loss Injury.
Passipieri JA, Hu X, Mintz E, Dienes J, Baker HB, Wallace CH, Blemker SS, Christ GJ. Tissue Eng Part A. 2019 Mar 18. doi: 10.1089/ten.tea.2018.0280. [Epub ahead of print]