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Reconstruction of Large Mandibular Defects Using Autologous Tissues Generated From In Vivo Bioreactors

Reconstruction of large mandibular defects is clinically challenging due to the need for donor tissue of appropriate shape and volume to facilitate high fidelity repair.

In order to generate large vascularized tissues of custom geometry, bioreactors were implanted against the rib periosteum of 3-4 year-old sheep for nine weeks. Bioreactors were filled with either morcellized autologous bone, synthetic ceramic particles, or a combination thereof.

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