An Osteo Science Foundation-funded research project.
The generation of bone tissue of clinically-relevant volumes is challenging due to oxygen diffusion limitations as tissues increase in size. To create and study tissue-engineered bone of large volume, we have designed an in vivo bioreactor sheep model capable of generating vascularized bony tissues. Our goal was to design a preclinical animal model in which the effects of different variables (such as scaffold selection, geometry, and host status) on the generation of large volumes of bone could be measured.
AM Tatara, SR Shah, E Watson, BT Smith, N Demian, IA Hanna, JC Melville, J Shum, T Ho, JJ van den Beucken, JA Jansen, ME Wong, AG Mikos “Ovine Model For Generation of Tissue-Engineered Vascularized Bone of Large Volume and Custom Geometry” Tissue Engineering Part A (22). 2016, Dec; S155-156