Ovine Model For Generation of Tissue-Engineered Vascularized Bone of Large Volume and Custom Geometry

Ovine
An Osteo Science Foundation-funded research project. 

The generation of bone tissue of clinically-relevant volumes is challenging due to oxygen diffusion limitations as tissues increase in size. To create and study tissue-engineered bone of large volume, we have designed an in vivo bioreactor sheep model capable of generating vascularized bony tissues. Our goal was to design a preclinical animal model in which the effects of different variables (such as scaffold selection, geometry, and host status) on the generation of large volumes of bone could be measured.

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Citation Information

AM Tatara, SR Shah, E Watson, BT Smith, N Demian, IA Hanna, JC Melville, J Shum, T Ho, JJ van den Beucken, JA Jansen, ME Wong, AG Mikos “Ovine Model For Generation of Tissue-Engineered Vascularized Bone of Large Volume and Custom Geometry” Tissue Engineering Part A (22). 2016, Dec; S155-156

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