Realization of complex three-dimensional structures associated with solid organs through bioprinting approaches presents considerable technical challenges.
Grigoryan et al. report in a recent article an innovative bioprinting approach leveraging a hydrogel material and food dye additives as photoabsorbers to control light penetration during the printing process.The technique enabled 3D-printing of complex vascular networks demonstrated through a variety of examples, including separate but intertwining vascular and airway network structures that supported oxygenation of human red blood cells perfused through the construct. The technologies described in the article enable production of complex topologies in biocompatible aqueous hydrogel systems that appear posed to overcome long-standing challenges in engineering approaches for tissue regeneration and may open exciting new frontiers for investigation.
Multivascular networks and functional intravascular topologies within biocompatible hydrogels.
Grigoryan B, Paulsen SJ, Corbett DC, Sazer DW, Fortin CL, Zaita AJ, Greenfield PT, Calafat NJ, Gounley JP, Ta AH, Johansson F, Randles A, Rosenkrantz JE, Louis-Rosenberg JD, Galie PA, Stevens KR, Miller JS. Science. 2019 May 3;364(6439):458-464. doi: 10.1126/science.aav9750.