Loss of alveolar bone after tooth extraction has motivated development of a variety of approaches for alveolar ridge preservation.
Many strategies involve application of a graft material to promote bone regeneration and increase bone volume in a post-extractive defect site. Synthetic biomaterials are emerging as potential alternatives to autografts, allografts, and xenografts as bone-void fillers in extraction sites. A recent article by Nieet al. applied naturally occurring silk fibroin from silkworm cocoons in the fabrication of porous scaffolds for alveolar bone regeneration. The team harnessed the collagen-like fibrous structure of the silk fibroin protein to facilitate nucleation of mineralization of the scaffolds with hydroxyapatite nanocrystals in vitro. The authors demonstrated that the mineralized scaffolds supported cell viability and osteogenesis in cell culture and induced bone formation in a rat tooth extraction model. Overall, the article suggests the potential of mineralized silk fibroin scaffolds as osteogenic grafts for alveolar ridge preservation after tooth extraction.
Nano-hydroxyapatite mineralized silk fibroin porous scaffold for tooth extraction site preservation.
Nie L, Zhang H, Ren A, Li Y, Fu G, Cannon RD, Ji P, Wu X, Yang S. Dent Mater. 2019:S0109-5641(19)30700-6.