Advances In Regenerative Medicine Article Image

Osteogenic magnesium incorporated into PLGA/TCP porous scaffold by 3D printing for repairing challenging bone defect

Scaffold-based approaches for bone regeneration often incorporate biologically active factors to facilitate desired outcomes, including bone formation and vascularization. Literature over the years suggests that magnesium may present osteogenic and angiogenic potential in certain contexts, which might be leveraged in regenerative medicine approaches to bone tissue repair.


A recent article by Lai et al. investigates the osteogenic and angiogenic effects of incorporation of magnesium into 3D-printed porous scaffolds comprising a degradable polymer and beta-tricalcium phosphate upon implantation into bony defects in a rabbit model. The authors report that the incorporation of magnesium into the scaffolds increased the compressive mechanical properties of the scaffolds without significantly affecting the porosity. Increased bone formation and vascularization was observed in the groups treated with scaffolds containing magnesium in rabbit ulnar defects and a rabbit model of steroid associated osteonecrosis. The article suggests that incorporation of magnesium into scaffolds presents potential to promote bone formation and angiogenesis in challenging bony defects.

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Citation Information:

Osteogenic magnesium incorporated into PLGA/TCP porous scaffold by 3D printing for repairing challenging bone defect.

Lai Y, Li Y, Cao H, Long J, Wang X, Li L, Li C, Jia Q, Teng B, Tang T, Peng J, Eglin D, Alini M, Grijpma DW, Richards G, Qin L. Biomaterials. 2019;197:207-219.

PMID: 30660996



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