Poly(Thioketal Urethane) Autograft Extenders in an Intertransverse Process Model of Bone Formation

Autograft bone serves as a standard option for bone regeneration in a variety of contexts in the craniomaxillofacial complex, due in part to the osteoinductivity generally presented by the graft tissue.

Autograft bone serves as a standard option for bone regeneration in a variety of contexts in the craniomaxillofacial complex, due in part to the osteoinductivity generally presented by the graft tissue. Nonetheless, the limited availability of autograft bone, patient morbidity, and other considerations motivate the development of autograft extenders to reduce the volume required to promote regeneration in bony defects. McGough et al. report in the following article the pre-clinical investigation of an innovative settable autograft extender based on a poly(thioketal urethane) polymer that degrades in response to reactive oxygen species produced by cells. The authors report cellular infiltration and bone formation within mixtures of autograft and the extender in a rat femoral segmental defect model, and they found that calcium phosphate granules can reduce the autograft content without compromising bone healing in a rabbit posterolateral intertransverse process model of bone formation. Overall, the article suggests the potential feasibility of the settable and degradable autograft extender for bone regeneration.

Continue Reading.

Citation Information:

Poly(Thioketal Urethane) Autograft Extenders in an Intertransverse Process Model of Bone Formation. McGough MAP, Shiels SM, Boller LA, Zienkiewicz KJ, Duvall CL, Wenke JC, Guelcher SA. Tissue Eng Part A. 2019 Jan 9. doi: 10.1089/ten.TEA.2018.0223. [Epub ahead of print]

PMID: 30398387

 

CONTACT

Osteo Science Foundation
1650 Market Street, Suite 3600
Philadelphia, PA 19103
215-977-2877
855-891-2877 Toll Free
info@osteoscience.org

Osteo Science Foundation is an independent, privately funded 501 (c) (3) non-profit organization.

SIGN UP FOR NEWS

By submitting this form, you are consenting to receive marketing emails from: Osteo Science Foundation, 1650 Market Street, Suite 2600, Philadelphia, PA, 19103, US. You can revoke your consent to receive emails at any time by using the SafeUnsubscribe® link, found at the bottom of every email. Emails are serviced by Constant Contact.