Autograft bone serves as a standard option for bone regeneration in a variety of contexts in the craniomaxillofacial complex, due in part to the osteoinductivity generally presented by the graft tissue. Nonetheless, the limited availability of autograft bone, patient morbidity, and other considerations motivate the development of autograft extenders to reduce the volume required to promote regeneration in bony defects.
McGough et al. report in the following article the pre-clinical investigation of an innovative settable autograft extender based on a poly(thioketal urethane) polymer that degrades in response to reactive oxygen species produced by cells. The authors report cellular infiltration and bone formation within mixtures of autograft and the extender in a rat femoral segmental defect model, and they found that calcium phosphate granules can reduce the autograft content without compromising bone healing in a rabbit posterolateral intertransverse process model of bone formation. Overall, the article suggests the potential feasibility of the settable and degradable autograft extender for bone regeneration.
Poly(Thioketal Urethane) Autograft Extenders in an Intertransverse Process Model of Bone Formation. McGough MAP, Shiels SM, Boller LA, Zienkiewicz KJ, Duvall CL, Wenke JC, Guelcher SA. Tissue Eng Part A. 2019 Jan 9. doi: 10.1089/ten.TEA.2018.0223. [Epub ahead of print]