Scalable MSC-derived Bone Tissue Modules

Emerging modular tissue engineering approaches seek to enable the generation of large-scale tissues from the assembly or fusion of small-scale cellular constructs generated in culture. While modular tissue engineering approaches present advantages with respect to maintaining cell viability in culture prior to assembly of the building blocks, generation of modular constructs with suitable mechanical properties for load-bearing bone regeneration presents a challenge.

 

A recent article by Miles et al. reports the application of a modular system comprising mesenchymal stem cells and hydroxyapatite microgranules encapsulated in polyelectrolyte complex membranes. The authors report that culture of the cell-laden microcapsules under osteogenic conditions promoted mineralization and facilitated subsequent fusion into macro-scale constructs capable of sustaining compressive loads. The authors suggest that the mineralized cell-laden microcapsules may provide a suitable basis for injectable or 3D-bioprinted scalable constructs for bone tissue regeneration in load-bearing sites.

 

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Citation Information:

Scalable MSC-derived bone tissue modules: In vitro assessment of differentiation, matrix deposition, and compressive load bearing.

Miles KB, Maerz T, Matthew HWT. Acta Biomater. 2019. doi: 10.1016/j.actbio.2019.01.014. [Epub ahead of print]

PMID: 30654211

 

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