Surgical precision and the use of biomaterials from autogenous, allogeneic, and xenogeneic sources can promote hard and soft-tissue growth and provide predictable outcomes. Recent clinical data underline the importance of a sufficient mucosal thickness to provide healthy peri-implant tissues and favorable esthetics. This lecture will describe clinical techniques and challenges to rebuilding an implant site and will feature biomaterials that support wound healing and new hard and soft-tissue regeneration. The importance of sufficient hard AND soft tissue will be highlighted. Aligning the correct procedure and biomaterials to the appropriate case selection and restorative option is vital to ensuring a stable and aesthetic result.