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Francesco R. Sebastiani, DMD

Sticky Dentin​: Autogenous Concentrated Growth Factor (ACGF) Enhanced Regenerative Matrix — A Randomized Controlled Double-Blinded Split-Mouth Study.

Francesco R. Sebastiani, DMD, participated in the Osteo Science clinical observership with Dr. Spagnoli in Southport, NC. Dr. Sebastiani earned a full athletic scholarship with Academic All-American and summa cum laude honors at Point Park University in Pittsburgh, PA. He is a graduate of the University of Pittsburgh School of Dental Medicine.
Dr. Sebastiani presented his research at AAOMS annual meetings, AO, AADR/IADR, ACOMS, NEIS, ADSA meetings. Dr. Sebastiani is the primary author on book and journal chapters on topics ranging from dynamic navigation during implant placement to oral sedation. His interests include biomimetic solutions for bone and soft tissue regeneration, implant reconstruction, and maxillofacial cosmetic surgery.



Over a 2-year period, 75 patients who require surgical extraction of both non-exposed partial or complete bony impacted mandibular third molars with IV sedation will be included. Inclusion criteria will be healthy patients less than 25 years old and a set of non-exposed partial or complete bony impacted mandibular third molars. Exclusion criteria will be patients whom the second molar is missing or indicated for extraction, patients with any underlying systemic disease or compromised immunity, and pregnant or lactating women.
In the study patients, after surgical extraction of the third molar on the case side, sticky dentin, an autogenous concentrated growth factor (ACGF) enriched dentin matrix composed of autogenous dentin particles stabilized with S-PRF along with H-PRF exudate will be placed in the socket followed by overlying H-PRF membrane and resorbable suture closure whereas on the control side, only resorbable suture closure will be performed. 
The outcome variables include alveolar osteitis, pain, edema, infection, periodontal regeneration, and bone formation and quality, with a clinical examination follow-up period of 1 week, 1 month, 3 month, and 6 months. Two doctors, whom did not perform the surgery and are unaware of the case and control sides, will evaluate each patient and record postoperative alveolar osteitis, pain, edema, infection, periodontal probing scores on the distal aspect of the second molar.
CBCT will be taken post-operatively; then one additional CBCT will be taken, either at 1 month, 3 months, or 6 months for evaluation of bone and periodontal regeneration at various time points. Bone core biopsy for histologic analysis at different post-extraction time points will be completed, once per patient at either 1 month, 3 months, or 6 months. Extensive histological analysis will be performed upon sticky dentin, S-PRF, H-PRF, H-PRF exudate, dentin particulates both prior to and after immersion in cleansing medicaments.


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