Jiabing Fan, MD, PhD is currently an assistant adjunct professor at UCLA. Dr. Fan’s research focuses on translating the genetic and molecular findings to developing novel therapeutic approaches for craniofacial repair and regeneration. He obtained his PhD from Sun Yat-sen University, China in 2010. Before joining UCLA, he completed his postdoctoral training at Harvard University. Dr. Fan has broad research background in stem cells, developmental biology, tissue engineering and drug/gene delivery across several international research institutes (NUS, Harvard, UCLA). He has received “outstanding mentorship award” at UCLA. He has published over 38 peer-reviewed articles, and several published in high caliber journals (ACS Nano, Biomaterials, etc.).
The objective of this proposed research is to develop a novel therapeutic approach targeting Trb3 for craniofacial bone repair in osteoporosis. Age-related osteoporosis is a major public health problem, characterized by imbalance of metabolism and bone remodeling due to increased marrow adiposity and reduced bone mass. Growing evidence shows that the osteoporosis is also associated with craniofacial bone loss, periodontitis, and tooth loss. The regeneration of bone injury in craniofacial osteoporosis remains a significant challenge. In particular, large craniofacial defects associated with significant bone loss usually require a more complex reconstructive intervention with a limited therapeutic effectiveness. Biologically compatible implants are capable of triggering the body’s natural ability to regenerate healthy osseous tissues in defect regions, presenting promise to larger craniofacial repair. Here, we develop a cell-free approach using EM-Trb3/scaffold complex for augmentation of mandibular defect repair in OVX animal model. The completion of the proposed studies will not just offer practical suggestion using Trb3 as a therapeutic target for craniofacial osteoporosis but also serve as the basis for future R01 proposal. Future studies will amplify current study in large animal model in vivo. Long-term goal will apply insights from this proposal to develop clinical approach for osteoporosis therapy and craniofacial bone regeneration.