Tracking Cells and Biomaterial Remodeling in Tissue Engineered Bone Grafts
Dr. Eisig is Chief of Hospital Dental Service at New York-Presbyterian Hospital, and the William Carr Professor and Director of Oral and Maxillofacial Surgery at both the Hospital and Columbia University School of Dental and Oral Surgery. He is a diplomat of the American Board of Oral and Maxillofacial Surgery and volunteers abroad by treating patients with cleft lip and palate on Healing the Children missions to South American countries. He practices full-scope oral and maxillofacial surgery, with a particular interest in orthognathic, craniofacial and cleft palate surgery, maxillofacial pathology and reconstruction, and pediatric oral and maxillofacial surgery.
Tissue engineered bone grafts present an attractive solution to the complexity involved in oral and maxillofacial bone grafts. Despite the functional success with tissue engineered bone grafts for bone reconstruction, little is known concerning the tissue engineered bone graft method of action and the fate of the implanted cells. In the proposed study, the implanted cell localization and contribution to bone regeneration will be investigated in a rat calvarial defect model. Utilizing genetically altered rat adipose derived stem cells (ADSCs) to fabricate our scientifically proven tissue engineered bone grafts, the objectives of the study will provide key information about the implanted stem cells concerning their function in reconstruction and site-localized safety. These results will not only benefit the clinical translation of tissue engineered bone grafts, but will provide important information to educate decisions regarding cell activity in tissue engineering applications in any targeted tissue.