Multiple channels in bioceramic scaffolds promote rapid vascularization and robust bone formation
Dr. Yunqing Kang received his PhD degree in Biomedical Engineering from Sichuan University, and did post-doctoral research in bone tissue regeneration from the Department of Osteopaedic Surgery, Stanford University. Currently, he is an Assistant Professor at Florida Atlantic University since 2014. Dr. Kang's research interest is craniofacial bone tissue regeneration.
Our goal in this project is to develop new functional bone scaffolds for the preservation of post-extraction sockets and alveolar bone augmentation. In this proposal we will use our developed template-casting method to create multiple hollow channels in porous β-TCP scaffolds. We will examine the effect of the channeled macroporous scaffolds on angiogenesis and osteogenesis in vitro, and we will also study the functionality of the multiple channels in the macroporous scaffolds to promote bone formation in a rat mandibular bone defects. The interconnection of hollow channels and macropores in the scaffold minimizes the diffusion distance of nutrient and blood supply, thus significantly promoting rapid vascularization and robust bone formation. This “off-the-shelf” scaffold will be convenient for dentists to directly use it with appropriate shaping treatments. This scaffold will have the potential not only for preservation of the post-extraction socket but also for bone regeneration of craniofacial bone defects in the future.
1. Kang Y. Chang J. Channels in a porous scaffold: a new player for vascularization. Future Medicine. Regenerative Medicine, Vol. 13, No. 6. Online, 24 Sep 2018. Full Text
2. Wang X., Lin M., and Kang Y. Engineering Porous β-Tricalcium Phosphate (β-TCP) Scaffolds with Multiple Channels to Promote Cell Migration, Proliferation, and Angiogenesis. ACS Applied Materials & Interfaces 2019 11 (9), 9223-9232. DOI: 10.1021/acsami.8b22041. Full Text
1. Xuesong Wang, Maohua Lin, Yunqing Kang. Channeled β-Tricalcium Phosphate (β-TCP) Scaffolds Promote Cell infiltration and proliferation. Society for Biomaterials. Seattle, WA. 2019 April 3-6.